Archives of Pharmacal Research
- 제20권1호
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- Pages.80-84
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- 1997
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- 0253-6269(pISSN)
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- 1976-3786(eISSN)
Synthesis of Substituted Cinnamoyl-tyramine Derivatives and their platelet Anti-aggregatory Activities
- Woo, Nam-Tae (Il-Yang Central Research Institute) ;
- Jin, Sun-Yong (Il-Yang Central Research Institute) ;
- Cho, Jin-Cho (Il-Yang Central Research Institute) ;
- Kim, Nam-Sun (Il-Yang Central Research Institute) ;
- Bae, Bae-Eun-Hyung (Il-Yang Central Research Institute) ;
- Han, Ducky (Il-Yang Central Research Institute) ;
-
Han, Byung-Hoon
(Natural Product Research Institute, Seoul National University)
;
- Kang, Young-Hwa (Natural Product Research Institute, Seoul National University)
- 발행 : 1997.02.01
초록
Substituted cinnamoyl-tyramine derivatives were synthesized by DCC-coupling of substituted cinnamic acid with tyramine or tyramine methyl-1-ether to evaluate PAF-receptor binding antagonistic activities and inhibitory activities on PAF-induced platelet aggregation with interest on structure-activity relations. The results show that 3,4-dimethoxy-cinnamoyl tyramine-amide or its methyl ether have significant PAF-receptor binding antagonistic activity and platelet anti-aggregatory activities.
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