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The Pharmaceutical Society of Korea (대한약학회)
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A Cytotoxic Constituent from Sophora flavescens

  • Kim, Youn-Kwan (College of Pharmacy, ChungNam National University) ;
  • Min, Byung-Sun (College of Pharmacy, ChungNam National University) ;
  • Bae, Ki-Hwan (College of Pharmacy, ChungNam National University)
  • Published : 1997.08.01
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Abstract

A cytotoxic constituent was isolated by bioassay-guided procedure from the roots of Sophora flavescens Aiton (Leguminosae). The constituent was identified as sophoraflavanone G (I) by means of chemical methods and in comparsion with spectral data of standard compound. The $ED_50$ values of constituent I were 0.78, 1.57, 2.14 and $8.59{\mu}g/ml$ against A549, HeLa, K562 and L1210 cell lines, respectively. Constituent I exhibited highly cytotoxic activities against A549, K562 and HeLa cells, but showed a mild activity $$(ED_50 value, 5{\mu}g/ml)$$ against L1210 cells. Among the tested cell lines, A549 cells were the most sensitive to constituent I.

Keywords

References

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