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The Pharmaceutical Society of Korea (대한약학회)
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Topical Anti-inflammatory Activity of Dianemycin Isolated from Streptomyces sp. MT 2705-4

  • Lee, Song-Jin (College of Pharmacy, Kangwon National University) ;
  • Kim, Hyun-Pyo (College of Pharmacy, Kangwon National University) ;
  • Park, Byung-Keun (Korea Research Institute of Bioscience and Biotechnology) ;
  • Ahn, Soon-Cheol (Korea Research Institute of Bioscience and Biotechnology) ;
  • Lee, Hyun-Sun (Korea Research Institute of Bioscience and Biotechnology) ;
  • Ahn, Jong-Seog (Korea Research Institute of Bioscience and Biotechnology)
  • Published : 1997.08.01
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Abstract

In order to develop new anti-inflammatory agents having different action mechanisms compared with nonsteroidal and steroidal anti-inflammatory drugs, the culture broths of various actinomycetes isolated from soil were screened using an in vivo mouse ear edma assay and one strain (Streptomyces sp. MT 2705-4: KCTC 8651 P) was selected. Activity-guided purification led to the isolation of a polyether compound, dianemycin. Topically, dianemycin showed a potent anti-inflammatory activity in mouse ear edema induced by croton-oil or arachidonic acid.$ED_{50}$value of dianemycin was found to be 0.8 mg,/ear compared to 0.4 mg/ear of prednisolone in croton-oil ear edema. However, dianemycin did not show the inhibitory activity in UV-erythema and delayed hypersensitivity reaction. These results indicate that dianemycin is a potential topical anti-inflammatory agent.

Keywords

References

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