흰쥐(SD rats)의 생리활성에 미치는 송엽(松葉) 추출물(PNE)의 영향 I. 혈청중의 지질 및 산소라디칼 대사에 미치는 PNE의 투여효과

Effect of Pine Needle Extract (PNE) on Physiological Activity of SD Rats I. Feeding Effect of PNE on Lipid and Oxygen Radical Metabolisms in Serum of SD rats

  • 최진호 (부경대학교 자연과학대학 식품생명과학과) ;
  • 김동우 (부경대학교 자연과학대학 식품생명과학과) ;
  • 김정화 (부경대학교 자연과학대학 식품생명과학과) ;
  • 김경석 (부경대학교 자연과학대학 식품생명과학과) ;
  • 이종수 (부경대학교 자연과학대학 식품생명과학과)
  • 발행 : 1997.12.01

초록

This study was edsigne to investgate the effect of pine needle extract (PNE) on lipid adn oxygen radical metabolisms in serum of Sprague-Dawly (SD). Pine(Pinus densiflora Sieb et Zucc.) is one of the popular plant drugs which gas been used as a medicine in Asia. Male SD rats were fed basic (control group) and experimental diets(RGE group) with 0.5 and 1.0% of PNE for 6 weeks. Body weights gain in 0.5-PNE and 1.0-PNE groups were slightly lower than that in control group, but ther is no significant differences brtween these groups. Total energy intake, feed and gross efficiencies showed almost no change in these groups. Total cholesterol and triglyceride (TG) levels in serumof SD rats in .50-PNE and 0.1-PNE froups sho9wed almost no change colpared with control group. Serum LDL-cholesterol levels significantly decreased (12%) in 0.5-PNE group, while serum HDL-cholesterol levels significantly increased(14%) in 1.0-PNE group compared with control group. Malondialdehyde (MDA) and lipid peroxide (LPO) levels in 50-PNE and 0.1-PNE groups were significantly lower (17 and 13%, 24% and 12%, respectively) than those in control group. Superoxide disumutase (SOD) activity in 50-PNE and 0.1-PNE groups significantly increased about 30 to 15% compared with control group. There results suggest that lower LDL-cholesterol and LPO levels, higher HDL-cholsterol level, and higher SOD activity in serum of rats may be effectively modulated by administration of pine needle extract(PNE).

키워드

참고문헌

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