Journal of the Korean Society of Food Science and Nutrition (한국식품영양과학회지)

The Korean Society of Food Science and Nutrition (한국식품영양과학회)
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Effects of Conjugated Linoleic acid(CLA) on the Growth of Tumor Cells and the Production of Interleukin-1 and Interleukin-2

Conjugated Linoleic Acid(CLA)의 암세포 증식 억제효과 및 Interleukin-1과 Interleukin-2의 생성에 미치는 영향

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  • ;
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  • Michael W. Pariza
  • 김소희 (동주여자전문대학 식품영양과) ;
  • 김광혁 (고신대학 의학부 미생물학교실) ;
  • 박건영 (부산대학교 식품영양학과) ;
  • Published : 1997.10.01
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Abstract

Conjugated dienoic derivatives of linoleic acid(CLA) are a series of positional and gemotric isomers of linoleic acid which are found naturally in food, mainly dietary products and breef. We studied the effects of CLA on the growth of tumor cells and the production of interleukin-1(IL-1) and interleukin-2(IL-2). CLA treatment markedly inhibited the growth of Yac-1 cells and sarcoma-180 cells by 99 and 82% to that of control, respectively, after four days of incubation at 37$^{\circ}C$. To elucidate the immunological mechanism of antitumor activity of CLA, spleen cells of Balb/c mouse were exposed to 31, 63, 125, 250 $\mu\textrm{g}$ of CLA per ml for 24 hrs at 37$^{\circ}C$. The culture supernatants of CLA-exposed spleen cells reduced the production of IL-1 and IL-2 in all of the test conditions. These results indicate that the anticarcino-genic effect of CLA was mediated by the other actions rather than the production of the Il-1 or IL-2. We suggest that CLA might have an antiinflammatory effect in part due to its inhibitory action on the production of IL-1.

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