Effect of Dietary Fibers Isolated from Tangerine Peels on Lipid and Cadmium Metabolism in the Rat

감귤과피로부터 분리한 식이섬유가 흰쥐의 지방 및 Cadmium 대사에 미치는 영향

  • 김미경 (이화여자대학교 식품영양학과)
  • Published : 1997.04.01

Abstract

This study was performed to investigate the effects of dietary fibers from tangerine peels on lipid and cadmium metabolism. And effects were compared with those of commercial dietary fibers($\alpha$-cellulose, citrus pectin). Sixty male rats of Sprague-Dawley strain weighing 186.7$\pm$2.6g were blocked into 12 groups according to body weight, and were raised for 2 weeks. Cadmium chloride was given at the levels of 0 of 400 ppm in diet. Various dietary fibers were given at the level of 0 or 4%(w/w) of diet. The results are summarized as follow. In lipid metabolism, insoluble fibers[insoluble dietary fibers from tangerine peels(IDE), $\alpha$-celluolse] increased fecal excretion of lipids by inhcreasing feces weight, and decreased the concentrations of serum triglyceride and liver lipids. Soluble dietary fibers from tangerine peels(SDF) decreased the concentrations of serum cholesterol and liver lipids by increasing fecal lipids, too. In cadmium metabolism, soluble fivers(SDF, pectin) inhibited Cd absorption by increasing fecal Cd excretion and decreased Cd concentrations of intestion, liver and kidney. In conclusion, among the extracted fibers, SDF were more effective on lipid and Cd lowering activity and IDF had effect of increasing fecal lipid excretion. This result is useful to reduce food waste and utilize waste products.

Keywords

References

  1. CRC Handbook of dietary fiber in human nutrition Influence of dietary fiber on cholesterol metabolism in experimental animals Kritchevsky,D.;Story,J.A.;Spiller,G.A.(ed.)
  2. J Nutr v.120 Fermentation of vegetable fiber in the intestinal tract of rats and effects on fecal bulking and bile acid excretion Nyman,M.;Schweizer,T.F.;Tyren,S.
  3. J Nutr v.119 Interaction of bile acids phospholipids, cholesterol and triglycerides with dietary fibers in the small intestine of rats Ebihara,K.;Schneeman,B.O.
  4. Am J Clin Nutr v.32 Effects of high and low fiber diets on plasma lipids and insulin Albrink,M.J.;Newman,J.;Davidson,P.C.
  5. Am J Clin Nutr v.59 Hypocholesterolemic effects of a dietary fiber supplement Donald,B.H.;Valery,T.M.;John,C.L.;Bruce,K.;Virgil,B.;Wm James,H.;Frank,J.D.;Robert,R.
  6. Toxicol Appl Pharmacol v.39 Biochemical and ultrastructural changes in livers of cadmium treated rats Faeder,E.J.;King,L.C.;Hinners,T.A.;Bruce,R.;Fower,B.A.
  7. Cadmium in the environment Friberg,L.;Piscator,M.;Nordberg,G.
  8. Minerals in Animal and Human Nutrition Macdowell,L.R.
  9. Environ Res v.42 Dietary fibers and heavy metal retention in the rat Rose,H.E.;Quarterman,J.
  10. Chem Pharm Bull v.30 Studies on poisonous metals Ⅸ. Effects of dietary fibers on absorption of Cd in rats Kiyozumi,M.;Mishima,M.;Moda,S.
  11. JAMA v.273 Protective effect of fruits and vegetables on development of stroke in men Gilman,M.W.;Cupples,L.A.;Gagnon,D.;Posner,B.M.;Ellison,R.C.;Castelli,W.P.;Wolf,P.A.
  12. Science v.264 Diet and health : What should we eat Willet,W.C.
  13. 국민영양조사보고서(해당년도) 보건사회부
  14. 전국통계연감 v.3 한국도시행정연구소
  15. 한국식품과학회지 v.9 no.4 한국산 감귤과피의 효율적 이용에 관한 연구(2) 장호남;남경은;허종화
  16. 한국식품과학회지 v.14 no.1 한국산 감귤류 폐과피 내의 펙틴 함량과 펙틴의 특성에 관한 연구 문수재;손경희;윤선;이명해;이명희
  17. 이화여자대학교 대학원 석사학위 논문 감귤과피로부터 분리한 식이섬유의 포도당, 담즙산, 카드뮴 투과 억제에 관한 in vitro 연구 양윤정
  18. J Assoc Off Anal Chem v.75 Determination of total, soluble and insoluble dietary fiber in food-enzymatic gravimetric method, MES-TRIS buffer : Collaborative study Lee,S.C.;Prosky,L.;DeVries,J.W.
  19. Can J Biochem Physiol v.37 A rapid method of total lipid extraction and purification Bligh,E.G.;Dyer,W.J.
  20. J Lab Clin Med v.78 Atomic absorption determination of lead in blood and urine in the presence of EDTA Zinterhofer,L.T.M.;Jotolow,P.T.;Fappiano,A.
  21. Environ Sci Technol v.5 Determination of lead in biological and related material by atomic absorption spectrometry Yeager,D.W.;Cholak,J.;Henderson,E.W.
  22. Toxicol Appl Pharmacol v.63 Comparison of metallothionein determination by polarographic and cadmium-saturation methods Onosaka,S.;Cherian,M.G.
  23. Toxicol Appl Pharmacol v.66 Evaluation of the Cd/Hb affinity assay for the rapid determination of metallothionein in biological tissue Eaton,D.L.;Toal,B.F.
  24. Methods Enzymol v.205 Determination of metallothionein in tissue by cadmium-hemoglobin affinity assay Eaton,D.L.;Cherian,M.G.
  25. Human physiology Kidneys and regulation of water inorganic ions Vander,A.J.;Sherman,J.H.;Luciano,D.S.
  26. 한국인 영양 권장량(6차 개정판) 한국영양학회
  27. 95년도 보건의료기술 연구개발사업 연구개발 결과 보고서 은종방;김미경;우희종;이서래;우건조;윤희남
  28. Arch Environ Health v.28 Renal and skeletal lesions in experimental cadmium poisoning : Histological and biological approaches Itokawa,Y.;Abe,T.;Tabei,R.;Tanaka,S.
  29. Toxicol Appl Pharmacol v.45 Effect of cadmium administration on growth, excretion and tissue accumulation of cadmium and historical alterations in calcium-sufficient and -deficient rats : An equalized feeding study Takashima,M.;Nishro,K.;Itokawa,Y.
  30. J Nutr v.84 Influence of dietary cadmium level and supplemental zinc on cadmium toxicity in the bovine Powell,G.W.;Miller,W.J.;Morton,J.D.;Clifton,C.M.
  31. Toxicol Appl Pharmacol v.39 Faeder,E.J.;Chaney,S.Q.;King,L.C.;Hinner,T.A.;Bruce,R.;Fowler,B.A.
  32. Arch Environ Health v.18 Turnover of cadmium 109 in rats Lucis,O.J.;Lynk,M.E.;Lucis,R.
  33. J Nutr v.107 Role of dietary calcium and calcium binding protein in cadmium toxicity in rats Washiko,P.W.;Cousins,R.J.
  34. Environ Health Pespect v.54 General aspects of cadmium : Transport, uptake and metabolism by the kidney Nordberg,M.
  35. Cadmium in health environment toxicity and carcinogenecity no.118 Metallothionein and tissue damage Manuel,Y.;Thomas,Y.;Pellegrini;Nordberg,G.F.(ed.);Herber,R.F.M.(ed.);Alssio,L.(ed.)
  36. Environ Health Pespect v.54 Dietary protein effect on cadmium and metallothionein accumulation in the liver and kidney of rats Revis,N.W.;Osborne,T.R.
  37. Toxicol Appl Pharmacol v.119 Nephrotoxicity of repeated injections of Cd-MT in rats Wang,X.P.;Chun,H.M.;Goyer,R.A.;Cherian,G.
  38. Toxicol Appl Pharmacol v.107 Gastrointestinal absorption of cadmium and metallothionein Ohta,H.;Cherian,M.
  39. Toxicol Appl Pharmacol v.109 Role of intestinal metallothionein in absorption and distribution of orally administered cadmium Min,K.S.;Fujita,Y.;Onosaka,S.;Tanaka,K.
  40. Toxicol Appl Pharmacol v.113 Degradation of cadmium metallothionein in Vitro by lysosomal proteases Min,K.S.;Nakatsubo,T.;Fujita,Y.;Onosaka,S.;Tanaka,K.
  41. Toxicol Appl Pharmacol v.117 Accumulation and degradation of protein moiety of Cd-MT in the mouse kidney Dorian,C.;Gatto,V.H.;Gattone,E.;Klaassen,C.D.
  42. Toxicol Appl Pharmacol v.31 Effects of dietary cadmium on rabbits Ⅰ. Early signs of cadmium intoxification Noriyama,K.;Sugata,Y.;Yamamoto,A.;Noriyama,H.
  43. Chem Pharm Bull v.30 no.12 Studies on poisonous metals Ⅸ. Effects of dietary fibers on absorption of cadmium in rats Morio,K.;Motohiro,M.;Sumiko,N.;Kazuyo,M.;Yoshihiro,T.;Fumie,M.;Mitsuo,N.;Shoji,K.
  44. Arch Intern Med v.151 Hypocholesterolemic effects of different bulk-forming hydrophilic fibers as adjuncts to dietary therapy in mild to moderate hypercholesterolemia Anderson,J.W.;Floore,T.L.;Geil,P.B.;O'Neal,D.S.;Balm,T.K.
  45. Am J Clin Nutr v.30 Effect of citrus pectin on blood lipids and fecal steroid excretion in man Kay,R.M.;Truswell,A.S.
  46. 한국영양학회지 v.28 no.1 식이섬유질의 종류가 흰쥐의 혈청지질농도와 장기능에 미치는 영향 김미정;이상선
  47. Biochem Biophys Acta v.152 Studies of the absorption of bile salts to non-absorbed components of diet Eastwood,M.A.;Hamilton,D.
  48. Nutr Rep Inter v.23 Soluble dietary fiber on plasma glucose and insulin responses in young man undergone glucose tolerance test Ebihara,K.;Masuharea,R.;Kiriyama,S.
  49. Gastroenterol v.67 In vitro adsorption of bile salts to food residues, salicyazosulfapyridine and hemicellulose Herman,J.B.;Fred,K.J.
  50. J Pharm Sci v.58 Quantification of the binding tendencies of cholestyramine Ⅰ: Effect of structure and added electrolytes on binding of unconjugated and conjugated bile-salt anion Johns,W.H.;Bates,T.
  51. Advanced nutrition and human metabolism Sara,M.H.;James,L.G.
  52. Proc Soc Exp Biol Med v.175 Propionate may mediate the hypocholesterolemic effect of certain soluble plant fiber in cholesterol-fed rats Chen,W.J.L.;Anderson,J.W.;Jennings,D.
  53. Lipids v.25 no.6 Contrasting effects of water-soluble and water-insoluble dietary fibers on bile acid conjugation and taurine metabolism in the rat Ide,T.;Horii,M.;Yamamoto,T.;Kawashima,K.
  54. J Nutr v.106 Influence of certain dietary fibers on serum and tissue cholesterol levels in rats Tsai,A.C.;Elias,J.;Kelley,J.J.;Lin,R.C.;Robson,J.R.
  55. Br J Nutr v.72 The effects of dietary sugarbeet fibre and guar gum on lipid metabolism in wistar rats Overton,P.D.;Furlonger,N.;Beety,J.M.;Chakraborty,J.;Tredger,J.A.;Morgan,L.M.
  56. Am J Clin Nutr v.59 Method of administration influences the serum cholesterol-lowering effect of psyllium Wolever,T.M.;Jenkins,D.J.;Mueller,S.;Boctor,D.L.;Ransom,T.P.;Pattern,R.;Chao,E.S.;McMillan,K.;Victor,F.
  57. N Engl J Med v.329 no.1 Effect of blood lipids of very high intakes of fiber in diets low in saturated fat and cholesterol Jenkins,D.J.;Wolever,T.M.;Rao,A.V.;Hegele,R.A.;Mitchell,S.J.;Ransom,T.P.;Boctor,D.L.;Spadafota,P.J.;Jenkins,A.L.;Mehling,C.
  58. Colon and Nutrition Polysaccharide fermentation in the human colon Cummings,J.H.;Kasper,H.(ed.);Goebell,H.(ed.)
  59. Postgrad Med J v.60 Constipation, dietary fibre and the control of large bowel function Cummings,J.H.
  60. Acta Pharmacol Toxicol v.59 no.7 Effect of dietary factors on GI Cd absorption in mice Schafer,L.;Anderson,O.;Nielson,J.B.
  61. Environ Res v.31 Tissue distribution of cadmium and metallothioneins as a function of day and dosage Cahill,A.L.;Nyberg,D.;Ehret,C.F.
  62. Environ Res v.40 Postlactational changes in cadmium retention in mice orally exposed to cadmium during pregnancy and lactation Bhatta Charyya,M.H.;Sellers,D.A.;Peterson,D.P.
  63. Environ Res v.42 no.1 Dietary fibers and heavy metal retention in the rat Rose,H.E.;Quarterman,J.