Journal of Nutrition and Health

The Korean Nutrition Society (한국영양학회)
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The Effects of Endogenous and Exogenous Estrogen on Risk Factors of Coronary Heart Disease -Part I : On Serum Lipid Levels-

내인성 및 외인성 Estrogen이 관상심장질환 위험인자에 미치는 영향 -제1보 : 내인성 및 외인성 Estrogen이 혈액 지질 농도에 미치는 영향-

  • 박유신 (한양대학교 생활과학대학 식품영양학과)
  • Published : 1997.04.01
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Abstract

To determine the effects of endogenous and exogenous strogen on serum lipid levels, twenty nonsmoking healthy Korean women were participated in this experiment for 12 weeks. They were assigned to three groups : (1) eight women aged 22 to 30(yr) for the premenopausal(Pre) group, (2) eight, aged 49 to 60(yr) for the postmenoparusal(Pst) group, (3) four, aged 23 to 30(yr) for the oral contraceptive(OC) group which used triphasic OC formulation. Fasting blood samples representing every phase of the hormonal levels were obtained from the subjects of the Pre and the OC group. From the subjects of the Pst group, fasting blood samples were obtained once per three weeks for 12 weeks. All the serum data were adjusted for dietary effects, exercise, personality type and body mass index(BMI) by using analysis of covariation(ANCOVA). Serum lipid levels of the three groups were significantly different. While serum levels of triglycerides(TG)(p<0.0001), low density lipoprotein-chloesterol(LDL-C)/high density liporotein-cholesterol(HDL-C) ratio (LDC-C/HDL-C)(P<0.01) and total cholesterol (TC)/HDL-C ratio (TC/HDL-C)(P<0.001) were significatnly high in the Pst group, serum HDL-C(P0.001) level was significantly high in the Pre group. The OC group showed significantly low serum TC(P<0.0001) and LDL-C(P<0.0001) levels. There was no signidicant difference in the fluictuation of serum lipid levels during the menstrual cycle of the Pre group. However, in the OC group, serum TG level was significantly increased at phase 2(P<0.05) where exogenous estrogen administration was highest. Even though other serum lipid levels of the OC group were not significantly fluctuated according to the exogenous estrogen administration, there was a trend of increased levels of serum TC, LDL-C, LDL-C/HDL-C and TC/HDL-C and decreased level of HDL-C during the menstruation period. Also, serum TC level was high(P<0.005) and serum TG level was low (P<0.005) at the baseline of the OC group compared with the periods of OC administration. When screening and counseling the female population at risk for coronary heart disease(CHD), the result of this study suggest that in may be desirable to divide the population into several groups according to their personal physiological characteristics, such as age, OC administration, menstrual cycle and menopause, as well as general risk factors for CHD.

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References

  1. 사망원인통계연보 no.13 통계청
  2. JAMA v.109 Coronary disease in youth : Comparison of 100 patients under 40 with 300 persons past 80 Glendy,R.E.;Levine,S.A.
  3. J Clin Endocrinol Metabol v.54 no.2 High density lipoprotein2 and hepatic lipase : eciprocal change produced by estrogen and norgestrel Tikkanen;Nikkila,E.A.
  4. Clin Chem v.34 no.8B The pathogenesis of atherosclerosis McGill,H.C.
  5. Am J Obstet Gynecol v.163 no.1 Role of plasma lipoproteins in the pathogenesis of atherosclerotic disease, with special reference to sex hormone effects Matti J.Tikkanen
  6. N Eng J Med v.320 Beyond cholesterol;Modifications of low-density lipoprotein that increase its atherogenicity Steinberg,D.;Parthasarathy,S.
  7. Lancet Jan 29 v.343 no.8892 Oestrogen and inhibition of oxidation of low-density lipoproteins in postmenopausal woman Sack,M.N.;Rader,D.J.;Cannon,R.O.3rd
  8. Atherosclerosis May v.99 no.2 Protective effect of 17 beta-estradiol against the cytotoxicity of minimally oxidized LDL to cultured bovine aortic endothelial cells Negre,S.A.;Pieraggi,M.T.;Mabile,I.;Salvayre,R.
  9. Clin Investig May v.71 no.5 Ovarian sex steroids and atherosclerosis Riedel,M.;Rafflenbeul,W.;Lichtlen,P.
  10. 인체생리학(개정 3판) 정영태
  11. Am J Obstet Gynecol v.133 Effects of long-term estrogen replacement therapy, 1 : Metabolic effects Hammond,C.B.;Jelovsek,F.R.
  12. Metabolism v.28 Changes in lipoprotein composition during the menstrual cycle Kim,H.J.;Kalkhoff,R.K.
  13. Master Thesis, The Ohio State University Fluctuation of serum lipid levels in premenopausal and postmenopausal women Lee,J.S.
  14. N Engl J Med v.305 Oral contraceptives and cardiovscular disease Stadel,B.V.
  15. Am J Obstet Gynecol v.161 no.5 The effect of triphasic oral contraceptives on plasma lipids and lipoproteins Wolfgang Patsch;Brown,S.A.
  16. Fertility and Sterility v.53 no.1 Influence of a triphasic oral contraceptive preparation on plasma lipids and lipoproteins Lussier-Canan,S.;Davignon,J.
  17. Atherosclerosis v.84 Comparison of the lipoprotein and hemostatic changes after a triphasic and a monophasic low dose oral contraceptives in premenopausal middle-aged women Cesare R. Sirtori;Calabresi,L.
  18. 한국인 영양 권장량(제6차 개정판) 사단법인 한국영양학회
  19. Type A behavior and your heart Friedman,M.;Rosenman,R.
  20. 식품영양정보 no.3 식이섭취조사 방법의 문제 김화영
  21. Diet and Health Methodological considerations in evaluating the evidence Burris,J.E.
  22. 식품성분표(제4차 개정판) 농촌진흥청 농촌영양개선연수원
  23. Enzymatic colorimetric method(COD-PAP) for the quantitative determination of total cholesterol and triglycerides in serum Wako Pure Chemical Industries, Ltd
  24. Enzymatic colorimetric method(COD-PAP) for the quantitative determination of HDL-Cholesterol in serum and plasma Wako Pure Chemical Industries, Ltd
  25. 대한내과학회잡지 v.38 no.5 관상동맥질환의 위험인자 서정돈
  26. 한국영양학회지 v.22 no.2 난소절제가 체조성에 미치는 장기적 영향 이상선;유정한
  27. Am J Physiol v.243 Obesity in Osborne-Mendel and S4B/P1 rats : Effects of sucrose solution, castration and treatment with estradiol or insulin Schemmel,R.A.;Teague,R.J.;Brau,G.A.
  28. Physiol Behavior v.8 Gonadal hormones and behavioral regulation of body weight Wade,G.N.
  29. 대한의학협회지 v.33 no.1 정상월경주기에 있어서 혈청성선자극호르몬(FSH, LH)및 성스테로이드호르몬(Estradiol, progesterone)의 분비에 관한 연구 유정옥;유한기
  30. 대한산부회지 v.28 no.11 폐경전기 여성의 월경주기중 혈중 뇌하수체 홀몬(LH, FSH)과 난소홀몬(Estradiol, Progesterone)의 변화에 관한 연구 유한기;유경자
  31. European J Clin Invest v.20 Platelet aggregability in humans : Contrasting in vivo and in vitro findings during sympatho-adrenal activation and relationship to serum lipids Larsson,P.T.;Hjemdahl,P.
  32. J Human Stress v.8 no.4 Stress, personality and serum-cholesterol level Lorenz,J.P.van Doornen;Orlebeke,K.F.
  33. JAMA v.253 Consensus Conference Statement;Lowering blood cholesterol to prevent heart disease
  34. Ann Intern Med v.87 Diabets, blood lipids and the role of the obesity in CHD risk for women : Framingham study Gordon,T.;Castelli,W.P.
  35. Ann Intern Med v.89 Menopause and coronary heart disease : Framingham study Tavia,G.;William,B.K.
  36. 대한산부회지 v.31 no.6 폐경기 여성에서의 증상, 지질변화 및 호르몬 변화에 대한 연구 김병창;김동호
  37. Am J Obstet Gynecol v.163 Metabolic changes during the normal menstrual cycle : A longitudinal study Lebech,A.M.;Kjaer,A.
  38. Br Med J v.2 Oral contraceptive use in older women and fatal myocardial infarction Mann,J.I.;Inman,W.H.W.
  39. Br Med J v.2 Myocardial infarction in young women with special reference to oral contraceptive practice Mann,J.I.;Vessey,M.P.
  40. Am J Obstet Gynecol v.163 Effects of oral contraceptives on lipid metabolism Gevers Leuven,J.A.;Dersjant-Roorda,M.C.
  41. Acta Obstet Gynecol Scand Suppl v.156 Selectivity and minimal androgenicity of norgestimate in monophasic and triphasic oral contraceptives Anderson,F.D.
  42. Am J Obstet Gynecol v.163 Time-dependent alterations in lipid metabolism during treatment with low-dose oral contraceptives Herbert Kuhl;Winfried Mrz
  43. Acta Obstet Gynecol Scand Suppl v.156 Comparison study of lipid and androgen metabolism with triphasic oral contraceptive formulations containing norgestimate or levonorgestrel Janaud,A.;Rouffy,J.;Upmalis,D.;Dain,M.P.
  44. Am J Obstet Gynecol v.126 Cigarette smoking, use of oral contraceptives and myocardial infarction Jain,A.K.
  45. J Clin Invest May v.91 no.5 Effects of low-dose oral contraceptives on very low density and low density lipoprotein metabolism Walsh,B.W.;Sacks,F.M.
  46. Fertility and Sterility v.53 no.1 Lipids, cardiovascular disease, and oral contraceptives : A practical perspective Upton,G.V.
  47. 가정의 v.7 no.6 호르몬 대체요법과 그 전망 이은화
  48. Obstet Gynecol v.72 The effects of estradiol on blood lipids and lipoproteins in postmenopausal women Lars Fahraeus
  49. 최신의학 v.255 no.26 Estrogen이 과지질혈증에 미치는 영향에 관한 실험적 연구 정도영;구자훈