약학회지 (YAKHAK HOEJI)

  • 제41권2호
  • /
  • Pages.153-160
  • /
  • 1997
  • /
  • 0377-9556(pISSN)
  • /
  • 2383-9457(eISSN)
대한약학회 (The Pharmaceutical Society of Korea)
권호 표지

천연물로부터 프롤릴 엔도펩티다제 저해제의 검색

Screening of Prolyl Endopeptidase Inhibitors from Natural Products

  • 이경희 (경북대학교 농과대학 농화학과) ;
  • 이현진 (경북대학교 농과대학 농화학과) ;
  • 박훈일 (경북대학교 농과대학 농화학과) ;
  • 홍은옥 (경북대학교 농과대학 농화학과) ;
  • 송경식 (경북대학교 농과대학 농화학과)
  • Lee, Kyung-Hee (Department of Agricultural Chemistry, College of Agriculture, Kyungpook National University) ;
  • Lee, Hyun-Jin (Department of Agricultural Chemistry, College of Agriculture, Kyungpook National University) ;
  • Park, Hun-Il (Department of Agricultural Chemistry, College of Agriculture, Kyungpook National University) ;
  • Hong, Eun-Ok (Department of Agricultural Chemistry, College of Agriculture, Kyungpook National University) ;
  • Song, Kyung-Sik (Department of Agricultural Chemistry, College of Agriculture, Kyungpook National University)
  • 발행 : 1997.04.01
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초록

One hundred and seventy crude drugs were screened for prolyl endopeptidase (PEP) inhibitors. Among them, 80% methanolic extract of 18 medicinal plants such as Polygonum cuspi data, Sanguisorba officinalis, Eugenia caryophyllata, Rubus coreanus, Cinnamomum cassia (Cassiae Cortex and Cinammomi Ramulus), Rheum palmatum, Ulmus pumila, Sorbus commixta, Areca catechu, Uncaria sinensis, Terminalia chebula, Caesalpinia sappan, Nelumbo nucifera, Machilus thunbergii, Paeonia moutan, Elscholtzia patrini and Cynomorium coccineum inhibited more than 70% of PEP activity at a concentration of 40 ppm. The active principles of P. moutan, M. thunbergii, T chebula, A. catechu, S. commixta, R. palmatum, R. coreanus, E. caryophyllata and P. cuspidata were transferred into organic solvents, which showed more than 75% inhibition at 5 ppm.

키워드

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