YAKHAK HOEJI (약학회지)

The Pharmaceutical Society of Korea (대한약학회)
권호 표지

Effects of UK 14,304, An ${\alpha}_2$-Adrenergic Agonist, on Renal Function in Dog

${\alpha}_2$-아드레날린 효능약인 UK 14,304의 신장기능에 미치는 영향

  • Published : 1997.08.01
Download PDF
⟨ Previous Next ⟩

Abstract

The effects of UK 14,304, an ${\alpha}_2$-adrenergic agonist, on renal function were investigated in dogs. UK 14,304, when given intravenousely($15.0{\mu}g/kg,\;50{\mu}g/kg$), produced the increase of urine flow accompanied with the marked augmentation of free water clearance ($C_{H_2O}$) and reabsorption rates of sodium in renal tubules ($R_{Na}$), and the remarkable decrease of osmolar clearance ($C_{osm}$) and the amounts of sodium excreted in urine ($E_{Na}$). UK 14,304 given into a renal artery($1.5{\mu}g/kg,\;5.0{\mu}g/kg$) elicited the increase of urine flow with the augmentation of $C_{H_2O}$ in both kidney. UK 14,304, when administered into carotid artery($3.0{\mu}g/kg,\;10.0{\mu}g/kg$). exhibited the same aspect as shown in intravenous UK 14.304 at smaller dose than the intravenous dose. Diuretic action of intravenous UK 14,304 were produced together with increase of $C_{H_2O}$ in situation of water diuresis too, changes of renal function in this state were the increase of $C_{osm},\;E_{Na},\;and\;E_K$ (excreted amounts of potassium in urine), and the decrease of $R_{Na}\;and\;R_K$, these were different appearances from situation of saline diuresis. Diuretic action of intravenous UK 14,304 were blocked completely by post or pretreatment of yohim-bine, ${\alpha}_2$-adrenergic blocking agents, and inhibited by pretreatment of vasopressin, antidiuretic hormone. Above results suggest that UK 14,304 produces the diuretic action by the inhibition of vasopressin secretion and suppression of electrolytes reabsorption of electrolytes in renal tubules mediated with central ${\alpha}_2$-adrenoceptor in dog.

Keywords

References

  1. Life Science v.43 Specific $[^3H]$ UK 14,304 binding in human cortex occurs at multiple high affinity states with alpha-2-adrenergic selectivity and differing affinities for GTP Andron, A.C.;Carlson, M.A.;Chapman Gilkeson
  2. Brit. J. Pharmacol. v.71 Interaction of selective α-adrenoreceptor antagonists with human and rabbit blood platelets Grand, J.A.;Scrutton, M.C.
  3. Mol. Pharmacol. v.28 Agonist and antagonist binding to alpha-2-adrenergic receptors in purified membranes from human platelets. Implications of receptor-inhibitory nucleotied-binding protein stoichiometry Neubig, R.R.;Gamtzos, R.D.;Brasier, R.S.
  4. Eur. J. Pharmacol. v.72 UK-14,304. A potent and selective $α_2$-agonist for the chracterizatio of α-adrenoreceptor subtypes Cambridge, D.
  5. Mol. Pharmacol. v.28 Alpha-2-adrenergic receptors in the human cell line. HT29. Characterization with the full agonist radioligand $[^3H]$ UK-14,304 and inhibition of adenylate cyclase Turner, J.T.;Ray-Pregner, C.;Bylund, D.B.
  6. Mol. Pharmacol. v.35 Interaction of full and partial agonists with HT29 cell $α_2$-adrenoceptor: Comparative study of $[^H3]$ UK-14,304 and $[^3H]$ clonidine binding Paris, H;Galitzky, J.;Senard, J.M.
  7. Am. J. Physiol. v.259 Modulation of vassopressin antidiuretic action by renal $α_2$-adrenoceptors Miclos, G.
  8. J. Pharmacol. Exp. Ther. v.247 Dose selective dissociation of water and solute excretion after renal alpha-2-adrenoceptor stimulation Blanford, D.E.;Smyth, D.D.
  9. Eur. J. Pharmacol. v.174 Enhanced natriuretic potency of intravenous clonidine: Extra renal sote of action Blanford, D.E.;Smyth, D.D.
  10. J. Pharmacol. Exp. Ther. v.240 JR: Renal effects of selective $α_2$ and $α_1$-adrenoceptor agonists in conscious. normotensive rats Gellai, M.;Ruffolo, R.R.
  11. Br. J. Pharmacol. v.97 The effect of medetomidine. and $α_2$-adrenoceptor agonist. on plasma artrial natriuretic peptide levels. hemodynamics and renal excretory functions in spontaneously hypertensive and Wister-Kyoto rats Ruskoaho, H.;Leppalouoto, J.
  12. Eur. J. Pharmacol. v.36 Clonidine-induced increase of renal prostaglandin activity and water diuresis in conscious dog Olsen, U.B.
  13. Kidney Int. v.7 Suppression of antidiuretic hormone secretion by clonidine in the anesthetized dog Humphreys, M.H.;Reid, I.A.
  14. 약학회지 v.27 Clonidine이 개의 신장기능에 미치는 영향 고석태;김기환
  15. 약학회지 v.32 개의 신장기능에 미치는 guanabenz의 영향 이상현;고석태
  16. J. Pharmacol. Exp. Ther. v.226 Jr:Synergistic effect of modest volume expansion on the diuretic and natriuetic action of guanabenz Strandhoy, J.W.;Morris, M.;Steg, B.D.;Buckalew, V.M.
  17. In Quantative Clinical Chemistry(Vol. 2) Methods Philips, R.A.;J.P. Peters(ed.);D.D. Van Slyke(ed.)
  18. J. Clin. Invest. v.24 The renal clearances of substituted hippuric acid derivates and other aromatic acid in dog and man Smith, H.W.;Finkelstein, N.;Aliminosa, L.;Crawford, B.;Graber, B.
  19. Statistical Methods(7th ed,) Snedecor, G.W.;Cochran, W.G.
  20. The Pharmacological Basis of Therapeutics(8th ed.) Gilman, A.G.;Rall, T.W.;Nies, A.S.;Taylor, P.
  21. Ibid
  22. In. Vasopression: Cellular and Integrative Functions Vasopression action in the kidney-overview and glomerular actions Margolis, B.;Angel, J.;Kremer, S.;Skorecki, K.;Cowley, A.W.(ed.);Liard, J.F.(ed.);Ausiello, D.A.(Ed.)
  23. Cell Tissue Res. v.152 Membrane associated particles : Distrbution in frog urinary bladder epitherium at rest and after oxytosin treatment Chevalier, J.;Bourgest, J.;Hugon, J.S.
  24. Comparative Physiology: Basic in Transport(Vol. Ⅱ) Water transport in epithelia Hays, R.M.;Kinne, R.(ed.)
  25. J. Clin. Invest. v.83 Vasopressin $V_1$ receptors on the principal cells of the rabbit cortical collecting tubule : Stimulation of cytosolic free calcium and inocitol phosphate production via couplingnto a pertussis tixub substrate Burnatowska-Hledin, M.A.;Spielman, W.S.
  26. Journal of R.I.M.S.K. v.2 Formation and excretion of urine Gill, W.S.
  27. Physiology of the Kidney and Body Fluids Pitts, R.F.
  28. Am. J. Physiol. v.219 Natriuresiss produced by vasopressin or hemorrhage during water diuresis in the dog Humphreys, M.H.;Friedler, R.M.;Earley, L.E.
  29. Am. J. Physiol. v.220 Natriuretic effects of vasopressin and cyclic AMP: Popssible site of action in the nephron Martinez-Maldonado, M.;Eknoyan, G.;Suki, W.N.
  30. J. Clin. Invest. v.44 The site of action of furosemide and other sulfonamide diuretics in the dog Suki, W.;Rector, F.C.;Seldin, D.W.
  31. 약물치료(기초와 임상) 임정규
  32. Pharmacol. Rev. v.35 Yohimbine: A parmacological probe for study of the α-adrebiceptor Goldberg, H.R.;Robertson, D.
  33. Research Biochemicals Intestinal The RBI Handbook of Receptor Classification Kebabian, J.W.;Neumeyer, J.L.
  34. Am. J. Physiol. v.247 Innervation of the renal corticol tubules: A quantitatives study Barajas, L.;Powers, K.;Wang, P.
  35. Federation Proc. v.44 Neural regulation of renal tubular sodium reabsorption and renine secretion DiBona, G.F.
  36. Am. J. Physiol. v.249 Water and electrolyte transport in Henle's loop and distal tubule after renal sympathectomy in the rat Bancsath, P.;Szenasi, G.;Takacs, L.
  37. Am. J. Physiol. v.243 Effect of renal stimulation on NaCl and $H_2O$ transport in Henle's loop of the rat DiBona, G.F.;Sawin, L.L.
  38. J. Physiol. v.352 The subtype of $α_2$-adrenoceptor involved in the neural control of renal tubular sodium reabsorption in rhe rabbit Hesse, I.F.A.;John, E.J.
  39. J. Pharmacol. Exp. Ther. v.209 Renal tubular site and mechnism of clonidine-induced diuresis in rats: Clearance and micropuncture studies Barr, J.G.;Kauker, M.L.
  40. Endocrinology v.104 Suppression of vasopressin release by clonidine: Effect of a $α_2$-adrenoceptor antagonists Reid, I.A.;Nolan, P.L.;Wolf, J.A.;Keil, L.C.
  41. Kidney Int. v.31 Inhibition of the tubular action of vasopressin by selective $α_2$-adrenoceptor agonists(Abstract) Gellai, M.;Edwards, R.M.
  42. J. Clin, Invest. v.73 Functional characterization of tje alpha-adrenergic receptor modulating the hydroosmotic effect of vasopressin on the rabbit cortical tubules Krothapali, R.K.;Suki, W.
  43. Am. J. Physiol. v.252 Renal $α_2$-adrenoceptor and the adenylate cyclase c-AMP system: Biochemical and physiological interactions Pettinger, W.A.;Umemura, S.;Smyth, D.D.;Jeffries, W.B.
  44. Adv. Cyclic Neuclrotide Res. v.12 Cyclic necleotides and tubule function Morel, F.;Imbert-Teboul, M,;Chabardes, M.
  45. Am. J. Physiol. v.259 Modulation of vasopressin antidiuretic action by $α_2$-adrenoceptors Gellai, M.
  46. Neuroendocrinology v.42 Central adrenergic control of vasopressin release Brooks, D.P.;Share, L.;Crofton, J.T.
  47. Endocrinology v.83 Further studies on the diuretic activity of antiuretic hormone Grinnel, E.H.;Kramar, J.L.;Duff, W.M.;Lydon, T.E.
  48. J. Pharmacol. Exp. Ther. v.221 JR: Renal effects of the antihypertensive guanabenz. in the dog. Strandhoy, J.W.;Morris, M.;Buckalew, V.M.