YAKHAK HOEJI (약학회지)

The Pharmaceutical Society of Korea (대한약학회)
권호 표지

Effect of Taurine on Hyperlipidemic Rats Fed Cholesterol and Vitamin $D_2$ containing Diet

콜레스테롤과 비타민 $D_2$ 첨가 사료로 유도된 흰쥐의 고지혈증에 대한 Taurine의 효과

  • Lee, Eun-Bang (Natural Products Research Institute, Seoul University) ;
  • Kim, Ok-Kyung (College of Natural Science, Seoul Women's University) ;
  • Jung, Chun-Sik (College of Pharmacy, Duksung Women's University) ;
  • Kim, Ju-Sun (Natural Products Research Institute, Seoul University)
  • 이은방 (서울대학교 천연물과학연구소) ;
  • 김옥경 (서울여자대학교 자연과학대학) ;
  • 정춘식 (덕성여자대학교 약학대학) ;
  • 김주선 (서울대학교 천연물과학연구소)
  • Published : 1997.08.01
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Abstract

Antihyperlipidemic effect of taurine was investigated in the hyperlipidemic rats induced by feeding a diet supplemented with cholesterol (1.5% in diet), vitamin $D_2$(1.25 million IU/kg of diet) and cholic acid (0.5% in diet). The rats were fed the diet containing 1% and 3% of taurine for 8 weeks. The contents of the cholesterol and triglycerides in the serum and liver of the hyperlipidemic rats were increased as compared with those of the control group. Feeding taurine resulted in decreases in total cholesterol and triglyceride levels. The HDL-cholesterol level in serum was decreased in the hyperlipidemic rats, but by administration of taurine its level was increased. In the aorta of the animals, total cholesterol and triglycerides contents were reduced significantly by treatment with taurine. The contents of calcium in the heart of hyperlipidemic rats were greatly increased as compared with those of the control group. Treatment of taurine produced significant decreases in calcium contents in the heart muscle of the animals. These results showed that the hyperlipidemic states in this model of rats were reversed by treatment of taurine.

Keywords

References

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