YAKHAK HOEJI (약학회지)

The Pharmaceutical Society of Korea (대한약학회)
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Effects of Tyrosine Phosphorylation Inhibitors on Vascular Smooth Muscle Contraction

혈광평활근 수축에 대한 타이로신 인산화 억제제의 효과

  • Jung, Jin-Young (College of Pharmacy, Chungbuk National University) ;
  • Yun, Yeo-Pyo (College of Medicine, Chungbuk National University) ;
  • Ahn, Hee-Yul (College of Pharmacy, Chungbuk National University)
  • Published : 1997.10.01
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Abstract

We studied effects of genistein and tyrphostin, inhibitors of tyrosine kinase, on contractions induced by high $K^+$ and norepinephrine in rat aorta. Genistein $(10^{-6}{\sim}10^{-4}M)$ and tyrphostin ($(10^{-5}{\sim}10^{-4}M)$) inhibited high $K^+$ and norepinephrine-induced sustained contractions, respectively in a concentration-dependent manner. High $K^+$ and norepinephrine caused an increase in $^{45}Ca^{2+}$ uptake while $10^{-4}M$ genistein and tyrphostin inhibited the $K^+$ and norepinephrine-increased $^{45}Ca^{2+}$ uptake, respectively. These results show that inhibitor of tyrosine kinase blocks the voltage-and receptor-operated $Ca^{2+}$ channels in rat aorta, respectively.

Keywords

References

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