Journal of radiological science and technology (대한방사선기술학회지:방사선기술과학)
- Volume 20 Issue 1
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- Pages.91-96
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- 1997
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- 2288-3509(pISSN)
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- 2384-1168(eISSN)
Radioprotective Effect of S-2(3-aminopropylamino)Ethyl Phosphorothioic Acid (WR-2721) on Lipid Metabolism in X-ray irradiated Rats
S-2(3-aminopropylamino)Ethyl Phosphorothioic Acid (WR-2721)가 방사선에 조사된 흰쥐의 지질대사에 미치는 영향
- Ko, Seong-Jin (Dept. of Radiotechnology of Ji San Junior College) ;
- Kim, Jae-Young (Dept. of Clinical Pathology of Ji San Junior College) ;
- Lee, Chun-Bok (Dept. of Biology of Kyung Sung University)
- Published : 1997.05.30
Abstract
Male rats of Albino strain were divided into four groups. The radioprotective effect of treatment with S-2(3-aminopropylamino)ethylphosphorothioic acid(WR-2721) using the dose of 200 mg/kg by intraperitonial injection on rats for 20 min prior to whole body x-ray irradiation (8 Gy) was studied. The harzardous effects of x-ray irradiation were greatly corrected In the treated group. The concentrations of total serum cholesterol, HDL-cholesterol, triglyceride, and phospholipid were greatly affected, showing insignificant changes in the treated group of animals. The drastic hyperglycemic effect of x-ray irradiation in the untreated group decreased to a normal level. These results show the potentiality of WR-2721 as a radioprotective agent.
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