Abstract
Antifungal activities of cinnamaldehyde derivatives against various fungi were investigated using paper disc diffusion method. Among the derivatives tested, ${\alpha}-chlorocinnamaldehyde$ was stronger than cinnamaldehyde in antifungal activity and was effective in inhibiting the growth of the representative fungi of dermatomycosis with minimum inhibitory concentration of $9.76{\sim}19.5\;{\mu}g/ml$. A comparison of antifungal activity of cinnamaldehyde derivatives revealed that antifungal action of cinnamaldehyde might be related to a basic structure of acrolein.
Cinnamaldehyde 유도체의 항진균활성을 조사한 결과 ${\alpha}-chlorocinnamadehyde$가 가장 항균활성이 우수한 것으로 평가되었다. ${\alpha}-Chlorocinnamaldehyde$는 피부진균증의 원인균주인 Tricophyton mentagrophytes, Microsporium gypseum, Epidermophyton floccosum, Cryptococcus neoformans, Aspergillus niger, Candida albicans와 Penicillium avellaneum에 대해 $9.8{\sim}19.5\;{\mu}g/ml$의 최소저지농도를 보였으나 시판중인 항진균제 clotrimzole보다는 역가가 낮은 것으로 나타났다. ${\alpha}-Chlorocinnamaldehyde$를 제외한 나머지 관련 유도체를 비교한 결과 phenyl기 주위의 유도체 화합물에서는 우수한 항균활성이 관찰되지 않았으며, acrolein기가 항균활성에 중요한 관능기로 작용하는 것으로 나타났다.
