The Journal of Korean Medicine (대한한의학회지)

The Society of Korean Medicine (대한한의학회)
권호 표지

The Experimetal Effects of PalMulTang on Anti-Cancer and Immunologic Function

팔물탕(八物湯)이 항암(抗癌) 및 면역기능(免疫機能)에 미치는 실험적(實驗的) 효과(效果)

  • Park, Hae-Jun (Dept. of Driental Surgery and Dermatology, College of Oriental Medicine, Dong-Eui University) ;
  • Ko, Woo-Shin (Dept. of Driental Surgery and Dermatology, College of Oriental Medicine, Dong-Eui University)
  • 박혜준 (동의대학교 한의과대학 외관과학교실) ;
  • 고우신 (동의대학교 한의과대학 외관과학교실)
  • Published : 1998.04.30
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Abstract

To investigate effect of water extract of PaIMuITang(PMT) on human cancer cell-lines and immunocytes, this research estimated proliferation of A431 cell line, KHOS-NP cell line, mouse thymocytes and mouse splenocytes, Nitric Oxide(NO) from macrophage, apoptosis and subpopulation of the mouse thymocytes. The results were obtained as follows; 1. PMT inhibited the. proliferation of A431 cell line, but it is not significant. 2. PMT inhibited the proliferation of KHOS-NP cell line, but it is not significant. 3. PMT stimulated the proliferation of mouse thymocytes, being compared Con A non-treated group. 4. PMT stimulated the proliferation of mouse splenocytes, being compared LPS treated group. 5. PMT l00g/mQ inhibited the production of NO from macrophages in vitro, being compared NPS IFN treated group. 6. PMT inhibited the production of NO from macrophages in vivo, being compared LPS|IFN treated group. 7. PMT accelerated the induction of apoptosis of the mouse thymocytes. 8. In subpopulation PMT decreased $T_H$ of the mouse thymocytes, but increased T /dT s of the mouse thymocytes.

Keywords

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