Journal of the East Asian Society of Dietary Life (동아시아식생활학회지)

The East Asian Society of Dietary Life (동아시아식생활학회)
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Effects of Dietary Fiber Sourecs on Lipid Metabolism and Kidney Function in Rats Fed High Cholesterol Diet

식이섬유 종류가 고콜레스테롤 식이를 급여한 흰쥐의 체내 지질대사 및 신장기능에 미치는 영향

  • 박영주 (서울대학교 생활과학대학 식품영양학과) ;
  • 박양자 (서울대학교 생활과학대학 식품영양학과) ;
  • 김민선 (서울대학교 생활과 학대학 식품영양학과)
  • Published : 1998.06.01
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Abstract

This study was conducted to investigate the effects of dietary fibers (cellulose ; polydextrose ; pectin ; ricebran) supplementation on the kidney fucntion of hyperlipidemic-induced rats on a high cholesterol diet (5% cholesterol). Serum lipid concentrations were not influenced by dietary fiber sources, but the pectin group was effective in reducing serum lipid levels. Total serum protein and albumin concentrations tended to higher in the polydextrose group, and serum creatinine and urea-N concentrations were higher in the pectin group than those in the other groups. Even though total urinary protein was high in the pectin group, GFR was reduced (18~30% decrease) as compared to other groups. The urea-N level was elevated in the polydextrose group as compared to that of cellulose group(25% increase). Total lipid, triglyceride and cholesterol concentrations in the liver of pectin group were lower than those of other groups. Total lipid and cholesterol concentrations in the kidneys were reduced in pectin and ricebran groups, respectively. The total cholesterol concentration infecal was significantly high in the polydextrose and pectin groups(p<0.05), and the triglyceride was highest in the pectin group. These results indicate no significant effects of dietary fiber supplementation on the kidney function of hyperlipidemic-induced rats on a high cholesterol diet, but pectin was very effective to improve lipid metabolism and to reduce GFR.

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References

  1. Diabetes v.37 Effect of proteinuria on mortality in NIDDM Robert,G.N.;David,J.P.;Michael,J.C.;Baird,H.R.;William,C.K.
  2. Nephron v.46 Dietary composition and renal function in healthy subjects Wiseman,M.J.;Hunt,R.;Goodwin,A.;Gross,J.L.
  3. Am.J.Clin.Nutr. v.47 Hyperlipidemia and the progerssion of renal diseasa Keane,W.F.;Kasiske,B.L.;O'Donnell,M.P.
  4. Lancet v.2 Lipid nephrotoxicity in chronic progressive glomerular and tubulo-interstitia disease Moorhead,J.F.;Nakos,E.I.;Chan,M.K.;Varghese,Z.
  5. Modern Nutrition in Health and Disease Nutrition,diet and the kidney Kopple,J.D.;Shils,M.E.(ed.);Olson,J.A.(ed.);Shike,M.(ed.)
  6. Kidney Int. v.28 Lowprotein diet prevents golmerular damage in adriamycin-treated rats Remuzzi,G.;Zoja,C.;Remuzzi,A.;Rossini,M.;Battaglia,C.;Broggini,M.;Bertani,T.
  7. Nephron v.50 no.3 Dietary protein manipulation in experimental nephrotic syndrome Feehally,J.;Baker,F.;Walls,J.
  8. Kidney Int. v.33 Focal and segmental glomerulosclerosis:Analogies to atherosclerosis Diamond,J.R.;Karnovsky,M.J.
  9. Life Sci. v.40 no.24 Dietary fat in experimental nephrotic syndrome:Beneficial effects of fish oil on serum lipids and indirectly on the kidney Ito,Y.;Barcelli,U.;Yamashita,W.;Weiss,M.;Thompson,B.;Kashyap,M.;Deddens,J.;Pollak,V.E.
  10. Lipids v.23 no.11 A diet containing ω-3 and ω-6 fatty acids favorably alters the renal phospholipids,eicosanoid synthesis and plasm lipids in nephrotic rats Barcelli,U.O.;Beach,D.C.;Thompson,B.;Weiss,M.;Pollak,V.E.
  11. 한국영양학회 v.21 no.3 식이중에 첨가된 섬유소의 종류와 수준이 흰쥐의 체내 지질 함량에 미치는 영향 서정숙;한인규
  12. 한국영양학회 v.27 no.4 식이섬유 첨가식이 Streptozotocin 유도 당뇨쥐의 장 기능과 지질 및 당질대사에 미치는 영향 박수현;이연경;이혜성
  13. Effects of polydextrose in the control of diabetes mellitus Kamejiro,Y.;Sono Sugawara;Ikuko Konoma
  14. 한국영양학회 v.28 no.2 식이섬유의 종류와 섭취수준이 고지방식을 섭취한 흰쥐의 체내 지질대사에 미치는 영향 장수정;박양자
  15. 한국영양학회 v.25 no.3 폴리덱스트로스와 가수분해된 구아검이 지방량을 달리한 식이르 섭취한 정상백서이 지질대사에 미치는 영향 최면;김종대;주진순
  16. Am.J.Clin.Patho. v.53 The colorimetric method for determination of serum total lipids based on the sulfo-fhosphovanillin reaction Fringe,C.S.;Dunn,R.T.
  17. Clin.Chem. v.21 A manual colorimetric assay of triglycerides in serum Biggs,H.G.;Erikson,T.M.;Moorehead,W.R.
  18. Anal Biochem. v.29 Study of a new cholesterol reagent Zlatkis,A.;Zak,B.
  19. Clin.Chem. v.18 Estimation of the concentration of low-density lipoprotein cholesterol in plasma without use of the preparative ultra centrifuge Friedewald,W.T.;Levy,R.J.;Frederickson,D.S.
  20. J.Biochem. v.226 A simple method for the isolation and purification of total lipids from animal tissue Folch,J.;Less,M.;Sloanestanley,G.H.
  21. 한국영양학회 v.26 no.1 식이중 Guar Gum과 Calcium 보충이 흰쥐의 체내 영양소 이용율에 미치는 영향 김상연;장유경
  22. 한국영양학회 v.20 no.1 영지,케일 및 sodium dextrothyroxine이 고콜레스테롤혈증 흰쥐의 호르몬 및 지질대사에 미치는 영향 정승용;김성희;김한수;정효숙
  23. 한국영양학회 v.26 no.1 갓의 급여가 흰쥐의 콜레스테롤대사에 미치는 영향 조영숙;방정로;박석규;전순실;정승용;하봉석
  24. Dietary fiber and intestinal absorption Vahouny,G.V.;Cassidy,M.M.
  25. J.Nutr. v.116 Effect of guar gum,lignin and pectin on proteolytic enzyme levels in the gastrointestinal tract of the rat:A time-based study Nalini,S.;Raymond,R.M.;Peter,L.D.
  26. New Engl.J.Med. v.268 Urinary hydroxyproline as an index of collagen turnover in bone Dull,T.A.;Hennman,P.H.
  27. Am.J.Clin.Nutr. v.30 Effect of citrus pectin on solid lipids and fecal steroid excretion in man Kay,R.M.;Truswell,A.S.
  28. J.PEN. v.11 Creatinine excretion as a measure of protein nutrition in adults of varing age Walser,M.
  29. J.Nutr. v.110 Studies on the mechanism of protein Induced hypocalciuria in older men and women Schuette,S.A.;Zemale,E.A.;Linkswiler,L.H.
  30. J.Nutr. v.120 Assessment of protein nutiritional status Young,V.R.;Marchini,J.S.;Cortiella,J.
  31. Dietary fiber and intestinal absorption Vahouny,G.V.;Cassidy,M.M.
  32. Modification of steroid excretion in response to dietary fiber Story,J.A.
  33. Br.J.Nutr. v.71 A study on the metabolism in heart and liver of cholesterol and pectinfed rats Hexeberg,S.;Hexebers,E.;Willumsen,N.;Berge,R.
  34. J.Nutr. v.120 The effect of dietary fiber feeding on cholesterol metabolism in rats Nishina,P.M.;Freedland,R.A.
  35. 한국영양학회 v.27 no.8 메밀급여가 streptozotocin 유발 당뇨쥐의 장기무게 및 당질과 지질대사에 미치는 영향 이정선;손흥수;맹영선;장유경;주진순
  36. J.Nutr. v.119 Interaction of bile acid phospholipids,cholesterol and tryglycerides with dietary fiber in the small intestine of rats Ebihara,K.;Schneeman,B.O.