Journal of the Korean Society of Food Science and Nutrition (한국식품영양과학회지)

The Korean Society of Food Science and Nutrition (한국식품영양과학회)
권호 표지

Studies on Anti-Mcirobial and Anti-Cancer Functions of Polysaccharide Extracted from Ganoderma lucidum

영지버섯 다당체의 항미생물작용 및 항암작용에 관한 연구

  • 김성환 (중부대학교 식품영양학과)
  • Published : 1998.12.01
Download PDF
⟨ Previous Next ⟩

Abstract

This study was carried out to elucidate the immunomodulating activity of protein bound polysac charide extracted from Ganoderma lucidum(PSG). Macrophage drived reactive radicals were known as an effector for antimicrobial and anticancer functions. The promising immune response molecule, reactive oxygen intermediates(ROIs), was determined in TIB 71 cells with PSG at various experimental conditions. Treatment with 0.5mg PSG significantly increased the production of ROIs, superoxide anion as well as hydrogen peroxide, from TIB 71 cells(p<0.001). Under the same concentration, con siderable results were obtained from 24 hour cultivation with 106 cells at 5% CO2 incubator. The cells were trigged with PMA(5.3 M) after primed BCG(100 M) or IFN (100U) alone could not induce the production of ROIs, but it had a significant potentiating effect on ROIs secretion when the cells were treated with PSG.

Keywords

References

  1. Principles of biochemistry Lehninger, A. L.
  2. 東醫寶鑑 허준
  3. 中藥大辭典 相賀徹夫
  4. 천연물 화학 천연물화학연구회
  5. Planta Med. v.55 Polysaccharides in pharmacy; current applications and future concepts Franz, G.
  6. 缶詰時報 v.55 キノコ類の呈味作用と藥理的效果 毛利威德
  7. 靈芝 久保道德
  8. 日本農藝化學會誌 v.58 マンネンタケ(靈芝)の 水溶性 多糖類の分畵,構造,抗腫瘍活性について 水野卓;加藤尙美;戶塚篤史;竹中一秀;新海健吉;淸水雅子
  9. Chem. Pharm. Bull. v.33 The biologically active constituents of Ganoderma lucidum(FR.) KARST : Histamine release-inhibitory triterpenes Kohda, H.;Tokumoto, W.;Sakamoto, K.;Fuji, M.;Hirai, Y.;Yamasaki, K.;Komoda, Y.;Nakamura, H.;Ishihara, S.;Uchida, M.
  10. J. Nutr. Sci. Vitaminol. v.34 Dietary effect of Ganoderma lucidum : Mushroom on blood pressure and lipid levels in spontaneously hypertensive rats Kabir, Y.;Kimura, S.;Tamura, T.
  11. Planta. Med. v.54 Effects of the extracts of Ganoderma lucidum on blood glucose level in rats Kimura, Y.;Okuda, H.;Arichi, S.
  12. 제3회 영지버섯 국제심포지움 학술발표회 초록 영지엑기스의 간중독 및 고지혈증에 대한 약효 정명현
  13. 제3회 영지버섯 국제심포지움 학술발표회 초록 영지버섯의 항염증작용 Stavinoha, W. B.
  14. 한국영양식량학회지 v.24 영지버섯에서 분리한 항암성 다당체의 연구 김성환;김을상;김영식
  15. 한국식품영양과학회지 v.26 영지버섯 다당체의 마우스 대식세포 면역증강 효과 김성환;김을상
  16. 한국균학회지 v.14 영지의 안전성에 관한 연구 김명자;김하원;이영순;심미자;최응칠;김병각
  17. 한국균학회지 v.15 영지추출물 및 Escherichia coli 배양액이 백혈구의 Chemotaxis에 미치는 영향 이미숙;정규선
  18. 한국균학회지 v.18 한국산 고등균류의 성분연구(제67보) 현진원;최응칠;김병각
  19. Chem. Pharm. Bull. v.38 Macrophage activation in vitro by chemically cross-linked(1→3)-β-D-Glucan Adachi, Y.;Ohno, N.;Ohsawa, M.;Oikawa, S.;Yadomae, T.
  20. Agric. Biol. Chem. v.49 Structures and antitumor activities of the polysaccharides isolated from fruiting body and the growing clulture of mycelium of Ganoderma lucidum Sone, Y.;Okuda, R.;Wada, N.;Kishida, E.;Misaki, A.
  21. 한국식품영양과학회지 v.27 영지버섯 다당체의 nitric oxide 생성능 및 생성기전 연구 김성환
  22. The macrophage in neoplasia The macrophage as a tumoricidal effector cell : A review of in vivo and vitro studies on the mechanism of the activator macrophage nonspecific cytotoxic reactions Hibbs, J. B. Jr.
  23. J. Exp. Med. v.149 Extracellular cytolysis by activated macrophages & granulocytes Nathan, C. F.;Silverstein, S. C.;Bruker, L. D.;Lohn, Z. A.
  24. Infection and Immunity v.59 Monocyte response to sulfatide from Mycobacterium tuberculosis : Inhibition of priming for interleukin-1 and tumor necrosis factor alpha and altered protein phosphorylation Brozna, J. P.;Horan, M.;Rademacher, J. M.;Pabst, K. M.
  25. J. Immunol. v.141 Release of reactive nitrogen intermediates and reactive oxygen intermediates from mouse peritoneal macrophages Ding, A. H.;Nathan, C. F.;Stuehr, D. J.
  26. Science v.236 The basis for the immunoregulatory of macrophages and other accessory cells Unanue, E. R.;Allen, P. M.
  27. Ann. Rev. Immunol. v.2 The cell biology of macrophage activation Adams, D.;Hamilton, T. A.
  28. Clin. Exp. Immunol. v.79 Stimulation of the respiratory burst and promotion of bacterial killing in human granulocytes by intravenous immunoglobulin preparations Marodi, L.;Kalmar, A.;Karmazsin, L.
  29. Pharmacol. Rev. v.43 Nitric oxide : physiology, pathophysiology and pharmacology Moncada, S.;Palmer, R. M. J.;Higgs, E. A.
  30. J. Immunol. v.146 Differences in the tumor necrosis factor-α mediated lysis by fixed natural cytotoxic cells and fixed cytotoxic macrophages Vanderslice, W. E.;Collins, J. L.
  31. J. Exp. Med. v.174 Inhibition of tumor cell ribonucleotide reductase by macrophage-derived nitric oxide Kwon, N. S.;Stuehr, D. S.;Nathan, C. F.
  32. Curr. Opinion. Immunol. v.3 Role of nitric oxide synthesis in macrophage antimicrobial activity Nathan, C. F.;Hibbs, J. B. R.
  33. J. Infect. Dis. v.27 L-Arginine-dependent reactive nitrogen intermediates and the antimicrobial effect of activated human mononuclear phagocytes Henry, W. M.;Rachel, F. T.
  34. J. Exp. Med. v.169 Nitric oxide : a macrophage product for cytostasis & respiratory inhibition in tumor target cells Stuehr, D. J.;Nathan, C. F.
  35. Anticancer Research v.12 The effect of Ganoderma lucidum on induction of differentition in Leukemic U937 cells Lieu, C. W.;Lee, S. S.;Wang, S. Y.
  36. J. Immunol. Method. v.97 Lucigenin chemiluminescence in the assessment of neutophil superoxide production Gyllenhammar, H.
  37. analytical applications of Bioluminescence and Chemiluminescence Dependence of PMNL luminol dependent chemiluminscence on oxygen Hallett, M. B.;Edwards, S. W.;Barrow, S. C. L.;Campbell, A. K.
  38. J. Immunol. Methods v.78 A semi-automated micro-assay for H₂O₂ release by human blood monocytes and mouse peritoneal macrophages Harpe, D. L. J.;Nathan, C. F.
  39. Medical Sciences v.87 Apparent hydroxyl radical production by peroxynitrite : Implications for endothelial injury from nitric oxide and superoxide Beckman, J. S.;Beckman, T. W.;Chen, J.;Marshall, P. A.;Freeman, B. A.
  40. Gann. v.74 Superoxide anion and hydrogen peroxide release by macrophage from mice treated with Norcardia rubra cell-wall skeleton : Inhibition of macrophage cytotoxicity by a protease inhibitor but not by superoxide dismutase and catalase Ito, M.;Suzuki, H.;Nakano, N.;Yamashita, N.;Sugiyama, E.;Maruyama, M.;Hoshino, K.;Yano, S.
  41. Products of oxygen metabolism in inflammation : Basic principles and clinical correlates Klebnoff, S. J.;Gallin, J. I.(ed.);Goldstein, I. M.(ed.);Snyderman, R.(ed.)
  42. J. Immunol. v.145 Tumor necrosis factor-α synergizes with IFN-γ in mediating killing of Leishmania major through the induction of nitric oxide Liew, F. Y.;Li, Y.;Millott, S.
  43. J. Immunol. v.139 Induction of nitrite/nitrate synthesis in murine macrophages by BCG Infection, Lymphokines or Interferon-γ Stuehr, D. J.;Marletta, M. A.
  44. Nonspecific defence mechanism : the role of nitric oxide nonspecific defence Liew, F. Y.;Cox, F. E. G.
  45. American type culture collection catalogue of cell lines and hybridomas(6th ed.) Hay, R.;Macy, M.;Chen, T. R.;McClintock, P.;Reid, Y.
  46. SPSS/PC + 를 이용한 통계분석 채서일;김범종