한국식품영양과학회지 (Journal of the Korean Society of Food Science and Nutrition)

  • 제27권5호
  • /
  • Pages.952-959
  • /
  • 1998
  • /
  • 1226-3311(pISSN)
  • /
  • 2288-5978(eISSN)
한국식품영양과학회 (The Korean Society of Food Science and Nutrition)
권호 표지

다시마섭취가 정상과 당뇨 생쥐 대식세포의 Cytokine 분비에 미치는 영향

Effect of Sea Tangel Intake on Cytokine Production in Macrophage from Normal and Diabetic Mice

  • 조성희 (대구효성가톨릭대학교 식품영양학과) ;
  • 양경미 (대구효성가톨릭대학교 식품영양학과) ;
  • 배복선 (대구효성가톨릭대학교 식품영양학과) ;
  • 임선아 (대구효성가톨릭대학교 식품영양학과) ;
  • 유리나 (울산대학교 식품영양학과)
  • 발행 : 1998.10.01
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초록

To investigate the effect of sea tangle on macrophage activity in normal and diabetic states, 10week old ICR mice were fed control(C) and sea tangle(S) diet containing 5%(w/w) cellulose and 13.6%(w/w) dry sea tangle for four weeks, after which two thirds of mice(CD and SD) were made diabetic by intramuscular injection of streptozotocin(150mg/kg bw). At 4th day after diabetes was apparent by urinary glucose, one half of diabetic mice(CDM and SDM) were treated with metformin(500mg/kg bw) orally. Peritoneal macrophages obtained from 3%-thioglycollate treated mice were cultured in the presence of lipopolysaccaride from Salmonella abortus equi(10$\mu\textrm{g}$/ml) for 24 hrs and tumor necrosis factor-$\alpha$(TNF$\alpha$), interleukin-1$\beta$(1L-1$\beta$)and prostaglandin E2(PGE2) were measured in culture media. Release of IL-1$\beta$and PGE2 from macrophage were increased in normal mice by sea tangle diet and had the same tedency in diabetic mice with or without metformin treatment although not statistically significant. Release of TNF$\alpha$ tended to be reduced by diabetes but were not changed significantly by sea tangle diet. Fatty acid compositions of macrophage and liver phospholipids showed that diabetes reduced arachidonic acid/linoleic acid ratio and sea tangle diet appeared to increase contentsof polyunsaturated fatty acids.

키워드

참고문헌

  1. 임상내분비학, 내분비 췌장 : 당뇨병 민헌기(편저)
  2. Diabetes v.44 Interferon expression in the pancreases of patients with type Ⅰ diabetes Huang, X. J.;Yuan, J.;Goddard, A.;Foulis, A.;James, R. F. L.;Lermark, A.;Pujolborrel, R.;Rabinovitch, A.;Somoza, N.;Stewart, T. A.
  3. Toxocology v.105 Immune-mediated side effects of cytokines in humans Vial, T.;Descotes, J.
  4. Diabetologia v.39 Elevated serum levels of macrophage-derived cytokines percedes and accompany the onset of IDDM Hussain, M. J.;Peakman, M.;Gallati, H.;Vergani, D.
  5. J. Clin. Invest. v.95 Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance Hotamisligil, G. S.;Arner, P.;Caro, J. F.;Atkinson, R. L.;Spiegelman, B. M.
  6. Biol. Pharm. Bulletin v.19 The diabetic state increases the activity but not the number of peritoneal macrophage in the G rat promoting the tube formation of cultured endothelial cells in rat aorta Kobayashi, S.;Luo, B.;Okabe, M.;Kimura, I.;Kimura, M.
  7. Diabetes v.29 Immunologic features of mice with streptozotocin-induced diabetes Ishibashi, T.;Kitahara, Y.;Harada, Y.;Harada, S.;Takamoto, M.;Ishibashi, Y.
  8. Hormone and Metabolic Res. v.27 Insulin-dependent reduction in hepatic and splenic contents of interleukin-1 beta in experimental diabetes Bistar, M. S.;Desouza, E. B.
  9. Functional foods, designer foods, phamafoods, nutraceuticals Goldberg, I.
  10. J. Nutr. v.121 Oral n-3 fatty acid supplementation suppresses cytokine production and lymphokine proliferation : comparison in young and older women Meydani, S. N.;Endres, S.;Woods, M. M.
  11. Surgery v.104 Fatty acid intake and Kuffer cell function : fish oil alters eicosanoid and monokine production to endotoxin stimulation Blliar, T.;Bankey, P.;Svingen, B.
  12. Nutr. Rev. v.48 Dietary modulation of cytokine production and biological functions Meydani, S. N.
  13. Abstracts from 42nd Fall Conference of Korean no.SL1 Immnu-regulating function of food Shirahata, S.
  14. 1997년 한국식품영양과학회 추례학술대회 초록 no.SL5 식품과 면역증진 효과-된장의 면역조절 기능과 그 작용기전 이봉기;장윤수;이숙이;정건섭;최신양
  15. Am. J. Clin. Nutr. v.57 no.SUP. Messengers and mediators : interactions among lipids, eicosanoids, and cytokines Endres, S.
  16. J. Biol. Chem. v.266 Inhibition of leukotriene A4 hydrolase/aminopeptidase by captopril Orning, L.;Krivi, G.;Bild, G.;Gierse, J.;Aykent, S.;Fitzpatrick, F. A.
  17. J. Cell. Biochem. v.161 Piroxicam and other cyclooxygenases inhibitors : potential for cancer chemoprevention Earnest, D. L.;Hixson, L. J.;Albert, D. S.
  18. 한국영양학회지 v.26 채소류 및 해조류 식품의 식이섬유 함량 김은희;맹영선;우순자
  19. 한국영양학회지 v.29 당뇨병 환자를 위한 고식이섬유 보충물의 개발을 위한 연구(Ⅱ) 이혜성;최명숙;이연경;박수현;김유정
  20. 한국식품영양과학회지 v.15 단기간의 식이섬유 첨가물 섭취가 인슐린 비의존성 당뇨병환자의 당질대사에 미치는 영향 이연경;이혜성;김보완
  21. 당뇨병 v.19 단기간의 식이섬유 첨가물 섭취가 인슐린 비의존성 당뇨병환자의 지질대사에 미치는 영향 이연경;이혜성;김보완
  22. J. Nutr. v.119 Carotenoids and the immune response Bendich, A.
  23. J. Nutr. v.116 Effect of dietary fat on the utilization of fatty acids by myocardial tissue in rat Lee, SH-C;Clandinin, M. T.
  24. Am. J. Clin. Nutr. v.166 Complementary medicine: a review of immunomodulatory effects of Chinese herbal medicine Borchers, A. T.;Hackman, R. M.;Keen, C. L.;Stern, J. S.;Gershwin, M. E.
  25. 식품성분표 제 5 개정판 농촌진흥청
  26. 한국수산학회지 v.9 해조류의 무기성분 이종우;성낙주
  27. 한국수산학회지 v.28 한국산 다시마 및 미역으로부터 fucoidan의 수출 및 정제 구재근;조길석;도정룡;우순자
  28. Radiats. Biol. Radioecol. v.34 The effect of translam on the natural resistance indices of the irradiated organism Kuzneetova, T. A.;Krylova, N. V.;Besednova, N. N.;Vasil'eva, V. N.;Zviagintseva, T. N.;Krashevski, S. V.;Eliakova, L. A.
  29. Korean Food Sci. Technol. v.5 Antitumor activity of seaweeds toward sarcoma-180 Ryu, B. H.;Kim, D. S.;Cho, K. J.;Sin, D. B.
  30. 한국영양학회지 v.31 다시마섭취가 정상과 당뇨쥐의 비장세포 증식에 미치는 영향 조성희;양경미;배복선;임선아;유리나
  31. International J. Immunopharmacology v.19 B-cell Stimulating activity of seaweed extracts Lin, J. N.;Yoshida, Y.;Wang, M. Q.;Okai, Y.;Yamashita, U.
  32. 최신면역학 강의 정태호;김정철;김문규
  33. Biochem. Biophys. Res. Comm. v.137 Regulation of macrophage tumor necrosis factor production by prostaglandin E₂ Kundel, S. L.;Wiggins, R. C.;Chensue, S. W.;Larrick, J.
  34. J. Leukoc. Biol. v.53 regulation by dietary essential fatty acid balance of tumor necrosis factor production in mouse macrophages Watanabe, S.;Onozaki, K.;Yamamoto, S.;Okuyama, H.
  35. Nature v.276 Complete protection from low-dose streptozotocin-induced diabetes in mice Rossini, A. A.;Williams, R. M.;Apple, M. C.;Like, A. A.
  36. Am. J. Clin. Nutr. v.63 The effect on human tumor necrosis factorα and interleukin 1β production of diets enriched in n-3 fatty acids from vegetable oil or fish oil Caughey, G. E.;Mantzioris, E.;Gibson, R. A.;Cleland, L. G.;James, M. J.
  37. 대구효성가톨릭대학교 박사학위논문 Streptozotocin 유발 당뇨쥐에서의 항혈전에 미치는 녹차 catechin의 영향 및 그 작용 기전 양정아
  38. Science & Medicine v.5 Role of cytokines in rheumatoid arthritis Starkebaum, G.
  39. Bioscience Biotechnology and biochemistry v.61 Activation of macrophage by sulfated glycopepptides in ovomucin, yolk membrane and chalazae in chicken eggs Tanizaki, H.;Tanaka, H.;Iwata, H.;Kato, A.
  40. International J. Immunopharmacology v.18 Strain differences in the cytotoxic activity and TNF production of murine macrophages stimulated by Lentinan Kerekgyarto, C.;Virag, L.;Tanko, L.;Chihara, G.;Fachet, J.
  41. Acta Pharmacologia Sinica v.18 Effects of 10-hydroxy-2-decenoic acid on phagocytosis and cytokine production of peritoneal macrophage in vitro Wang, G. Y.;Lin, Z. B.
  42. Eur. J. Immunol. v.23 The involvement of CD14 in stimulation of cytokine production by uronic acid polymers Espevik, T.;Otterlei, M.;Skjak, B. G.;Ryan, L.;Wright, S. D.;Sundan, A.