Journal of the Korean Society of Food Science and Nutrition (한국식품영양과학회지)

The Korean Society of Food Science and Nutrition (한국식품영양과학회)
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Modulation of Anticarcinogenic Enzyme and Plasma Testosterone Level in Male Mouse Fed Leek-Supplemented Diet

부추 첨가 식이가 수컷 생쥐의 암예방 효소계 및 혈중 웅성호르몬 농도에 미치는 영향

  • 김정상 (인제대학교 식품과학연구소 및 식품영양학과) ;
  • 곽연주 (인제대학교 기초과학연구소) ;
  • 전희정 (숙명여대 식품영양학과) ;
  • 이민자 (인제대학교 식품과학연구소 및 식품영양학과) ;
  • 권태완 (인제대학교 식품과학연구소 및 식품영양학과)
  • Published : 1998.10.01
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Abstract

Allium tuberosum Rotter(Liliaceae) is a perennial herb of which leaves are used for food. Leek has been reported to have pharmacological effects including alleviations of abdominal pain, diarrhea, hematemesis, snakebite, and asthma. To investigate the effect of dietary leek supplementation on the drug-metaboizing enzymes, quinone reductase(QR) and arylhydrocarbon hydroxylase(AHH) activities in the liver, stomach, small intestine and lung, and on the plasma testosterone and dihydrosterone hormone levels, mice were fed 2% and 5% leek diets for 8 weeks. Quinone reductase, an anticarcinogenic enzyme, was significantly induced in stomach, small intestine, and lung but slightly lowered in hepatic tissue in the experimental groups compared to control group. Arylhydrocarbon hydroxylase activity, involved in bioactivation of procarcinogens, was significantly decreased in liver and lung. Leek feeding led to the reduction in the plasma level of dihydrotestosterone which is associated with the incidence of prostate cancer. These findings support the potential chemopreventive activity of leek supplementation.

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