Journal of the Korean Society of Food Science and Nutrition (한국식품영양과학회지)

The Korean Society of Food Science and Nutrition (한국식품영양과학회)
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Effect of Mungbean Sprouts Juice on Cadmium-Induced Hepatotoxicity in Rats

녹두나물 생즙이 카드뮴에 의한 흰쥐의 간손상에 미치는 영향

  • 이명렬 (조선대학교 식품영양학과) ;
  • 최인화 (조선대학교 식품영양학과) ;
  • 김성오 (동신전문대학 환경위생과) ;
  • 김경수 (조선대학교 식품영양학과)
  • Published : 1998.10.01
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Abstract

The effects of mungbean sprout juice on cadmium-induced hepatotoxicity in rats were investigated. Sprague-Dawley rats weighing about 90g were divided into 4 groups and raised for 6 weeks. ; control group(CON), mungbean sprouts juice-administered group(MSJ), cadmium-administered group(CAD) fed water containing 40 ppm cadmium chloride and mung bean sprouts juice and cadmium-administered group(MCD). The diet was supplied every day for the measurement of feed efficiency ratio(FER) and net weight gain was measured every 3 days. The activities of serum glutamic oxaloactic transaminase(GOT) and glutamic pyruvic transaminase(GPT), superoxide dimutase(SOD), catalase and glutathione peroxidase(GSH-Px) in the liver and the hepatic contents of glutathione were examined. The contents of Cd in liver and kidney of the rats were determined by using ICP(Inductively Coupled Plasma Emission Spectrophotometer). Growth rate and FER were decreased in CAD group, compared with CON group but the changes were not significant in MCD group. The activities of serum GOT and GPT, SOD, catalase and GSH-Px in the liver were increased by Cd administration, but the alterations were decreased by supplementation with mungbean sprouts juice. The level of glutathione decreased in CAD group(26.8$\pm$9.0mg/g liver), whereas it increased in MCD group(36.4$\pm$15.8mg gliver). The content of Cd in the liver and kidney in MCD group(9.57 ppm, 4.88 ppm) was decreased, compared with CAD group(12.81 ppm, 5.46 ppm). This result suggested that mungbean sprout juice has a lowering effect on the accumulation of Cd in the liver and kidney and it is believed that the juice has some protective effects to Cd-induced hepatotoxicity in rats, but the mechanism of these effects was obscure.

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References

  1. 한국식물도감 이창복
  2. 식품보감 유태종
  3. 한국영양식량학회지 v.18 녹두 발아에 미치는 초음파 조사의 영향 고무석;이유방
  4. 대한가정의학회지 v.3 숙주의 영양생장과 한국적 조리에 의한 비타민 C의 소장에 관한 연구 이성우
  5. 국민영향 v.95-4 녹두이용 음식의 유래와 그 조리 과학성 박혜원
  6. 和漢藥 赤松金芳
  7. 약학회지 v.34 녹두의 성분연구 신순희;강상식;권경숙
  8. 한국영양식량학회지 v.17 녹두의 유리 및 결합 지질의 조사에 관한 연구 엄수현;최홍식
  9. 한국영양식량학회지 v.19 녹두의 전분지질에 관한 연구 엄수현;송영옥
  10. 중앙대학교 박사학위논문 급성 카드뮴 중독시의 hydrogen peroxide의 생성, catalase 및 $Na^+,\;K^+$, ATPase활성도의 변화와 ascorbate, diethyldithio-carbamate(DDTC), glutathione 및 α-tocopherol의 방어효과 김정용
  11. Arch. Environ. Health. v.24 Cadmium and zinc binding in mammalian liver and kidneys Shaikh, Z. A.;Lucis, O. J.
  12. Research Communications in Chem. Path. and Phar. v.74 Binding of cadmium to alcohol dehrogenase in the liver before induction of metallothionein Suzuki, K. T.;Sunaga, H.;Yamane, Y.;Aoki, Y.
  13. Eur. J. Biochem. v.139 Characterization of Cd-Zn thionein (Metallothionein) isolated from rat and chicken liver Weser, V.;Rupp, H.;Donay, F.;Linneman, F.;Volter, W.;Jung, G.
  14. 중앙대학교 박사학위논문 카드뮴 급성 폭로에 의한 metallothionein 생성과 조직병리 소견 민경준
  15. 전북대학교 박사학위논문 흰쥐에 있어서 쇠뜨기 식이의 카드뮴 중독 방어효과 정영호
  16. Biological roles of metallothionein Foulkes, E. C.
  17. 효성여자대학교 석사학위논문 카드뮴으로 급성 중독된 흰쥐의 간장 및 신장에서의 metallothionein 합성에 관한 연구 김수영
  18. Toxicol. Appl. Pharmacol. v.77 Cdmium-induced hepatic cadmium metallothionein in nephrotoxicity Dudley, R. E.;Grammal. L. M.;Klaassen, C. D.
  19. Toxicol. Appl. Pharmacol. v.74 Tolerance to cadmium-induced hepatotoxicity following cadmium pretreatment Goering, P. L.;Klaassen, C. D.
  20. British J. Industrial Medicine v.50 A nine year follow up study of renal effects in workers exposed to cadmium in a zinc are refinery Sittert, N. J.;Ribbens, P. H.;Huisman, B.;Lugtenburg, D.
  21. Environ. Health Perspect. v.28 Renal tubular disfunction and abnormalities of calcium metabolism in cadmium workers Kazantizis, G.
  22. 한국영양학회지 v.19 카드뮴 투여 흰쥐의 혈청 및 간장 성분에 미치는 식이성 비타민 E 와 단백질의 영향 김혜짐;조수열;박종민
  23. Toxicology v.34 Effects of three proteins absorption of cd in rats Kojima, S.
  24. Health Perspect. v.54 Dietary protein effects on Cd and metallothionein accumulation in the liver and kidney of rats Kavis, N. M.;Osborne, T. R.
  25. 한국영양식량학회지 v.21 카드뮴 투여가 흰쥐 간조직의 과산화적 손상에 미치는 영향 이순재;김성옥
  26. 한국영양식량학회지 v.23 식이성 아연 수준이 카드뮴 중독에 미치는 영향 조수열;김명주
  27. J. Nutr. v.107 Ad. Hoc. Comittee on standards for nutritional studies American Institute of Nutrition
  28. Methods in enzymology v.53 Preparation and assay of superoxide dismutase Crapo, J. D.;McCord, J. M.;Fridovich, I.;Fleischer, S.(ed.);Packer, L.(ed.)
  29. Methods in enzymology(3rd ed.) v.3 Catalase Abei, H.;Bergmeyer, H. U.(ed.);Bergmeyer, J.(ed.);Grabl, M.(ed.)
  30. J. Lab. Clin. Med. v.70 Studies on the quantitatative and qualitatative characterization of erythrocyte glutathione peroxidase Paglia, E. D.;Valentine, W. N.
  31. Anal. biochem. v.27 Enzymatic method for quantitative determination of nanogram amounts of total and oxidized glutathione Tietze, F.
  32. Am. J. Clin. Pathol. v.28 A colorimetric method for the determination of serum glutamic oxaloacetic determination and glutamic pyruvic transaminase Reitman, S.;Frankel, S.
  33. J. Clin. Invest. v.34 A note on the spectrophotometric assay of glutamic oxaloacetic transaminase in blood serum Karman, A.
  34. J. Biol. Chem. v.193 Protein measurement with folin phenol reagent Lowry, C. H.;Rsenbrough, N. J.;Farr, A. L.;Randall, R. J.
  35. J. Nutr. v.101 Effect of ascorbic acid on cadmium toxicity in the young couturnix Fox, M. R. S.;Fry, Jr. B. E.;Harland, B. F.;Schertel, M. E.;Weeks, C. E.
  36. 한국영양식량학회지 v.23 한국산 녹차, 우롱차 및 홍차와 음료의 cadmium제거 작용에 관한 연구 김미지;이순재
  37. J. Bacteriol. v.114 Induction of superoxide dismutase by molecular oxygen Gregory, E. M.;Fridovich, I.
  38. Bioch. Pharm. v.42 Effects of ethanol on Cd-induced lipid peroxidation and antioxidant enzymes in rat liver Sharma, G. R.;Gill, K. D.
  39. Nutr. Rev. v.38 Structure, synthesis and function of glutathione peroxidase Sunde, R. A.;Hoekstra, W. G.
  40. J. Nutr. v.114 Effect of dietary fat on plasma glutathione peroxidase levels and intestinal absorption of $^{75}Se-labled$ sodium selenite in chicks Mutanen, M. L.;Mykkanen, H. M.