Journal of Nutrition and Health

The Korean Nutrition Society (한국영양학회)
권호 표지

The Effects of Dietary Ca Levels on Ca and Skeletal Metabolism in Ovariectomized Rats of Different Age

난소를 절제한 나이가 다른 흰쥐에서 식이 칼슘 수준이 골격 대사에 미치는 영향

  • 김화영 (이화여자대학교 가정대학 식품영양학과)
  • Published : 1998.05.01
Download PDF
⟨ Previous Next ⟩

Abstract

To investigate the effect of dietary Ca levels on metabolic changes of Ca and skeleton in postmenopausal women, 10-month-old ovariectomized female rats were compared with 2 month old rats. The rats were fed either 0.2% or 1.2% Ca diets for 16 weeks. Food intake and weight gain as higher in rats fed high Ca diets and in ovariectomized rats. Apparent Ca absorption as higher, and Ca balance was lower in the low Ca groups. Vertebrae density was higher in old rats or those fed a high Ca diets. The old rats and ovariectomized rats showed decreased bone formation, increased bone resorption and kidney function deterioration resulting in increased urinary Ca excretion. Contradictory to the above observation, old rats and ovariectomized rats still showed higher bone mass and bone ash content. Therefore aging was not fully onging in 10-month-old rats. Bone weights, mineral contents, and mineral/wt ratio were lower in ovariectomized rats. Dietary Ca level did not affect urinary Ca excretion, urinary protein excretion, GFR, serum alkaline phosphatase, or urinary hydroxyporline excretion. This means that dietary Ca level did not influence kidney function or bone turnover. However Ca content and the ash content of femur, 4th vertebra, and scapula were increased in high Ca groups. Therefore, it is considered that decreased bone formation and accelerated bone resorption may account for the increased osteoporotic risk in women in menopause after middle age. However, Ca metabolism can be improved and bone components can be maintained if Ca is supplemented.

Keywords

References

  1. Kor J Orthoped v.27 Correlation of the osteoporosis and abnormal bone fracture Kim,S.J.;Cho,J.R.;Han,J.H.;Cho,S.S.
  2. Bone Mineral v.9 The pathogenesis of osteoporosis Gallapher,J.C.
  3. Am J Med v.75 Evidence for two distinct syndromes of involutional osteoporosis Riggs,B.L.;Melton,L.J.Ⅲ
  4. Calcif Tissue Int v.41 Bone density in diagnosis of osteoporosis: Threshold and breakpoints Mazess,R.B.
  5. Korean J Nutr v.28 no.4 Effect of estrogen and dietary protein level on Ca and skeletal metabolism in ovariectomized rats Kim,W.Y.;Kim,M.H.
  6. J Bone Jt Surg v.49A Ca deficiency and osteoporosis Riggs,B.L.;Kelley,P.J.;Kinney,V.R.;Scholaz,D.A.;Blanco,A.J.Jr.
  7. Korean J Nutr v.26 no.2 Ca and osteoporosis in Korean Kim,S.H.
  8. Korean J Nutr v.27 no.6 Nutritional status of Korean elderly people Kang,M.H.
  9. Aging Kim,S.H.;Kim,W.Y.
  10. Ann Intern Med v.87 Effect of Estrogens and calcium carbonate on bone loss in postmenopausal women Recker,R.R.;Saville,P.D.;Heaney,R.P.
  11. Korean J Nutr v.28 no.5 A study of the long term effects of dietary protein level on Ca and skeletal metabolism in ovariectomized rats Kim,W.T.;Moon,K.W,;Kim,J.H.
  12. Clinical Medicine Lee,K.N.;Kim,J.K.
  13. Anal Biochem v.83 A simplification of the protein assay method of Lowry et al which in more generally applicable Peterson,G.L.
  14. Anal Biochem v.55 A quick and specific assay hydroxyproline Blumenkrantz,N.;Asboe-Hansen,G.
  15. Practical physiological chemistry Hawk,P.B.;Oser,B.L.;Summerson,W.H.
  16. Physiol Behav v.17 Overian influence on the meal patterns of female rats Blaustin,J.D.;wade,G.N.
  17. Bone v.16 Response of femoral neck to estrogen depletion and parathyroid hormone in aged rats Wronski,L.
  18. A Master's Thesis, Graduate school,Ewha Womans University The effects of dietary protein and Ca intake on Ca and skeletal metabolism in female rats Kim,S.H.
  19. Bone Mineral v.18 Effect of oophorectomy on biochemical and variables in the rat Morris,H.A.;Porter,S.J.;Dudridge,T.C.;Moore,R.J.;Need,A.C.;Nordin,B.E.C.
  20. New Engl J Med v.17 Urinary hydroxyproline as an index of collagen tumover in bone Dull,T.A.;Henneman,P.H.
  21. J Nutr v.118 The effect of dietary calcium on bone metabolism in young and aged female rats using a short term in vivo model Sinha,R.;Smith,J.C.;Soares,J.H.
  22. Korean J Nutr v.26 no.8 The effect of dietary protein level on the Ca and bone metabolism in ovariectomized rats Cho,S.Y.;Jang,Y.A.;Lee,H.S.;Kim,W.Y.
  23. Am J Clin Nutr v.39 Effect of clacium supplementation on urinary hydroxyproline in osteoporotic postmenopausal women Horowitz,M.;Need,A.J.;Philcox,J.C.;Nordin,B.E.C.
  24. Korean J Gerontology v.3 The effect of dietary protein level on kidney function and on Ca metabolism in rats of different ages Ahn,J.W.;Kim,W.Y.
  25. J Bone Min Res v.4 no.s Reduced glomerular filtration and a renal tubular Ca leak in woman with primary osteoporosis Yendt,E.R.;Cohamin,;Jarzylo,S.
  26. Am J Physiol v.260 Effect of dietary calcium on bone density on gowing rabbits Gilsanz,V.;Roe,T.F.;Antunes,J.;Carlson,M.;Duarte,M.L.;Goodman,W.G.
  27. Am J Clin Nutr v.52 Factors that influence peak bone mass formation : a study of calcium balance and the inheritance of bone mass in adolescent females Matkovic,V.;Fontana,D.;Tominac,C.;Goel,P.;Chesnut,C.H.Ⅲ
  28. Kidney Int v.7 Effect of nephron reduction and dietary protein content on ammoniagenesis in the rat Schoolwerth,A.C.;Sandler,R.S.;Hoffnan,P.M.;Klahrs
  29. J Nutr v.109 Effect of level of protein intake on calcium metabolism and on parathyroid and renal function in the adult human male Yunghee,K.;Hellen,M.L.
  30. Endocrinology v.124 The aged rat model of ovarian hormone deficiency bone loss Dike,N.K.;Chung-Ching,L.;Robert,R.H.;Bruce,W.H.
  31. Endocrinology v.123 Estrogen treatment prevents osteopenia and depresses bone turnover in ovariectomized rats Wronski,T.J.;Cintron,M.Doherty,A.L.;DAnn,L.M.
  32. Ann Int Med v.101 Marked disparity between trabecular and cortical bone loss with age in health men Meier,D.E.;Orwoll,E.S.;Jones,J.M.
  33. Epidemiol Rev v.7 Epidemiology of osteoporosis and osteoporotic fracture Cummings,S.R.;Kelsy,J.L.;Nevitt,M.C.;O'Dowd,K.J.
  34. Am J Clin Nutr v.44 Relationships between usual nutruent intake and bone mineral content of women 36-65 years of age: longitudinal and cross-sectional analysis Freudenheim,J.L.;Johnson,N.E.;Smith,E.L.
  35. J Nutr v.117 Effect of calcium supplementation on forearm bone mineral content in postmenopausal women : a prospective , sequential controlled trial Polley,K.J.;Nordin,B.E.C.;baghurst,P.A.;Walker,C.J.;Chatterton,B.E.
  36. Proc. Soc Exp Biol Med v.116 Effect of dietary calcium levels on production and reversal of experimental osteoporosis in cats Jowsey,J.;Gershon-Cohen,J.
  37. J Nutr v.120 Effect of calcium citrate-malate on skeletal development in young growing rats Kochanowski,B.A.
  38. J Clin Endocrinol Metab v.42 Histological studies of bone from normocalcemic postmenopausal osteoporotic patients with increased circulating parathyroid hormone Teitelbaum,S.L.;Rosenberg,E.M.;Richardson,C.A.;Avioli,L.V.
  39. New Engl J Med v.316 Does calcium supplementation prevent postmenopausal osteoporosis? Riis,B.;Thomsen,K.;Christiansen,C.
  40. J Nutr v.111 Long-term effects of level of protein intake on calcium metabolism in young adult women Hegsted,M.;Linkswiler,H.M.
  41. J Nutr v.110 Studies on the mechanism of protein-induced hypercalciuria in older men and women Schuetle,S.A.;Zemel,M.B.;Linkswillwe,H.M.
  42. J Nutr v.105 Effect of a high protein intake on Ca metabolism in the rat Bell,R.R.;Sie,T.L.;Draper,H.H.;Engelmann,D.T.