Inhibitory Effect of Artemisia princeps Pampan.. Extract on Growth of Cancer Cell Lines

쑥(Artemisia princeps Pampan) 추출 성분의 암세포증식 억제효과

  • 황윤경 (수원여자대학교 식품조리학과)
  • Published : 1998.05.01

Abstract

To investigate the antitumor activity of mugwort (Artemisia princeps Pampan), petroleum ether extract of mugwork was partially purified by a silica gel chromatography. Among several fractions, the fraction which was obtained under the elution with acetone, showed potent cytotoxicity against mouse leukemia cell line(Ll210), human colon cancer cell line (HCT-48) and human hepatoma cell line (Hep G2) , but was less effective with normal cell line(mouse embryo cell). Acetone fraction appeared to be glycolipid by Benedict test and the major fatty acids of the lipid were C16 ; 0 , C 18: 3by GC/MS analysis.

Keywords

References

  1. J Nati Cancer Inst v.58 Contribution of environment to cancer medicine Wynder,E.L.;Gori,G.B.
  2. Fed Proc. v.35 Prevention of chemical carcinogenesis by vitamin A and its synthetic analogs(retinoids) Sporn,M.B.;Dunlop,N.M.;Newton,D.L.;Smith,J.M.
  3. Chem Pharm Bull v.29 no.12 Structural examination of a water soluble antitumor polysaccharide of Ganoderma lucidum Miyazaki,T.;Nishijima,M.
  4. J Korean Soc Food Nutr v.20 no.4 Naturally-occuring novel anticarcinogenes:Conjugated dienoic derivatices of linoleic acid(CLA) Ha,Y.L.;Michael,W.P.
  5. Cancer Research v.30 Fractionation and purification of the polysaccharides with marked antitumor activity, especially Lentinan, from Lentinus edodes(Berk) sing Chihara,G.;Hamuro,J.;Maeda,Y.;Arai,Y.;Fukuoka,Y.
  6. Kor J Pharmacogn v.3 Statistical studies on the formularies of oriental medicine(Ⅰ);Prescription frequency and their origin distribution of herb drugs Hong,M.H.
  7. Kor J Pharmacogn v.8 Potential anticancer medicinal plants;A statistical medicine formularies Cha,S.M.
  8. Korean Biochem J v.15 no.3 A study on the pharmacological activities of korean medicinal herbs. Mainly on the antitumor activities Hwang,W.I.;Lee,S.D.;Oh,S.K.
  9. Korean J Nutrition v.23 no.2 A study on the cytotoxic activity of Galic(Allium sativum) extract against cancer cells Son,H.S.;Hwang,W.I.
  10. Korean J Ginseng Sci v.8 no.2 Effects of petroleum ether extract of ginseng root on some enzyme activity in human colon cancer cells Hwang,W.I.;Oh,S.K.
  11. Korean J Food Sci Technol v.30 no.1 Effect of Platycodon grandiflorum DC extract on the growth of cancer cell lines Lee,J.Y.;Hwang,W.I.;Lim,S.T.
  12. Kor J Pharmacogn v.25 no.2 Antimeoplastic effect of extracts from traditional medical plants and various plants Hyun,J.W.;Lim,K.H.;Shin,J.E.;Sung,M.S.;Won,Y.J.;Kim,Y.S.;Kang,S.S.;Chang,I.M.;Woo,W.S.;Paik,W.H.
  13. J Korean Soc Food Nutr v.14 no.2 A study on the nutritonal effects in rats by feeding basal diet supplmented with mugwort powder Haw,I.W.;Lee,S.D.;Hwang,W.I.
  14. A Medical Phytology(the details) Lim,K.H.
  15. J Korean Soc Food Nutr v.23 no.2 Volatile flavor compounds from raw mugwort leaves and parched mugwort tea Kim,Y.S.;Lee,J.H.;Kim,M.N.;Lee,W.G.;Kim,J.O.
  16. J Korean Soc Food Nutr v.21 no.3 Antimutagenic effect of the major volatile compounds identified from mugwort(Artemisia asictica nakai) Kim,J.O.;Kim,Y.S.;Lee,J.H.;Kim,M.N.;Rhee,S.H.;Moon,S.H.;Park,K.Y.
  17. J Korean Soc Food Nutr v.21 no.1 Antioxidative effectiveness of water extract and ether extract in wormwood(Artemisia montana Pampan) Lee,G.D.;Kim,J.S.;Bae,J.O.;Yoon,H.S.
  18. J Pharmaceu Sci v.68 no.7 Antivacterial activity of Artemisia herba-alba Yashphe,J.Segal,R.;Breuer,A.;Erdreich-Nartali,G.
  19. Kor J Pharmacogn v.7 no.1 Pharmacognostical investigation on the oriental medicine(Ⅱ);Botanical origin of usual vegetable drugs Cho,H.W.;Ryo,K.S.
  20. Mutat Res v.204 no.2 Antimutagenic activity of extracts from anticancer drugs in Chinese medicine Lee,H.;Lin,J.Y.
  21. INT J Immunopharmacol v.11 no.6 Immunological mechanisms of antitumor activity of some kinds of crude drugs on tumor necrosis factor production Xu,Q.;Mori,H.;Sakamoto,O.;Uesugi,Y.;Koda,A.
  22. Rastit Resur v.25 no.2 The antitumor activity of phenol compounds from some Artemisia spp L. Ryakhovskaya,T.V.;Ushbaeva,G.G.;Zhemaletdinov,F.G.
  23. Korean J Food & Nutrition v.5 no.1 A study on the growth inhibition of human colon cancer cells by eucommial leaf extract Hwang,W.I.
  24. Korea Univercity Medical Journal v.20 no.1 The inhibitory effect of water extracts of the trchosanthes semen and synapsis semen against some cancer cells growing Lee,C.S.;Ju,J.S.;Hwang,W.I.
  25. Korea Univercity Medical Journal v.25 no.1 Effect of Prunus mume extract on the growth rate of animal leukemic cells(L1210,P388) and human colon cancer cells(HRT-18,HCT-48,HT-29) Lee,T.H.;Paik,J.M.;Hwang,W.I.
  26. Proc. Symp Wakan-Yaku v.12 Antitumor activity of crude drugs with human tissue culture screening Sato,A.;Nakano,Y.;Taguchi,T.
  27. Meth In Med Res v.10 Devalopment maintenance and assay of drug resistance Fischer,G.A.;Sartorelli,A.G.
  28. Cell Culture v.LⅧ Methods in Enzymology Jakoby,W.B.;Pastan,I.H.(ed.)
  29. A manual of basic technique(2nd edition) Cuture of animal cells Freshney
  30. Blood v.37 Colony formation by normal and leukemic human marrow cells in culture effect of conditional medium from human leucocytes Isove,N.N.;Senn,J.S.;Ill,J.E.;McCulloch,E.A.
  31. Exp Cell Res v.25 The serial cultivation of human diploid cell strains Hayflick,I.;Moorhead,P.
  32. Korean Biochem J v.13 no.1 Determination of antitumor effects of extracts from korean medicinal plants on cancer cells(L5178Y) Hwang,W.I.;Cha,S.M.;Lee,S.Y.
  33. Lipids v.25 no.9 Fatty acid content of marine oil capsules Chee,K.M.;Gong,J.X.;Rees,D.M.G.;Meydani,M.M.;Ausman,L.;Johnson,J.;Sinuel,E.N.;Schaefer,E.J.
  34. Experimental biochemistry
  35. Staining Procedures(4th edition) Clerk,G.
  36. Korea Univercity Medical Journal v.25 Determination of antitumor effects of extracts from Korean medicinal plants on cancer cells Kim,K.S.;Paik,J.M.;Hwang,W.I.
  37. Biochem Phamacol v.17 The incorporation of ³H-cytosine arabinoside and its effect in murine leukemic cells(L5178Y) Chu,M.Y.;Fischer,G.A.
  38. Cancer Res v.42 Effect of sodium butyrate on alkaline phosphatase in HRT-18, a human rectal cancer cell line Morita,A.;Jsao,D.;Kim,Y.S.
  39. Korea Univercity Medical Journal v.30 A Study on the Cytotoxic Activity of Polyacethylene of Ginseng against Hep G2(Hepatoma) and L929 Cells, in vitro Kim,I.H.;Hwang,W.I.
  40. Korean J Ginseng Sci v.17 no.1 A Study on the Antitumor Activity of Panax ginseng Hwang,W.I.