Journal of Nutrition and Health

The Korean Nutrition Society (한국영양학회)
권호 표지

Effect of Antioxidant vitamin Supplementation on Blood Composition in Smoking College Men

항산화성 비타민 보충 급여가 흡연자의 혈액성상에 미치는 영향

  • 이성숙 (전남대학교 가정대학 식품영양학과)
  • Published : 1998.04.01
Download PDF
⟨ Previous Next ⟩

Abstract

A large body of epidemiologic evidence suggests inverse relationships between ischemic heart disease and plasma vitamin C and E concentrations. Smokers have lower plasma concentrations of these vitamins than do nonsmokers. Smokers therefore need antioxidant vitamin supplementation . The purpose of study was to investigate the effect of antioxidant vitamin supplementation on blood composition in smoking college men. 24 subjects were divided into 3 groups of which were the vitamin C supplementation group(n=8), the vitamin E supplementation group(n=8), and the vitamin C+E supplementation group(n=8). The vitamin supplementation group consumed 500mg of ascorbic acid, the vitamin E supplementation group consumed 200IU of D-$\alpha$-tocopherol , and the vitamin C+E supplementation group consumed 500mg of ascorbic acid +200IU of D-$\alpha$-tocopherol for 4 weeks. We examined the blood compositions of the volunteers bofore and after vitamins were supplemented . The results obtained were as follows ; intakes of energy , carbohydrate , fat protein , vitamin C and vitamin E were not significantly affected by vitamin supplementation in all groups. Blood glucose concentrations were not significantly affected by vitamin supplementation in all groups. Concentrations of plasma uric acid and alkaline phosphatase activity were decreased significantly (p<0.05) with vitamin E supplementation. The results of this study show that antioxidant vitamin supplementation in smokers has a tendency to decrease coronary heart disease risk.

Keywords

References

  1. Br. J. Nutr. v.69 Nutrient intake by duration of ex-smoking in the scottish heart health story Bolton-smith,C.;Woodward,M.;Brown,C.A.;Tunstall-pedoe.H.
  2. Am. J. Clin. Nutr. v.45 Plasma levels of antioxidant vitamins in relation to ischemic heart disease and cancer Gey,K.F.;Brubacher,G.B.;Stahelin,H.B.
  3. Lancet v.337 Risk of angina pectoris and plasma concentrations of vitamin A, C, and E and carotene Riemersma,R.A.;Wood,D.A.;Macintyre,C.C.A.;Elton,R.A.;Gey,K.F.;Olicer,M.F.
  4. N. Engl. J. Med. v.328 A prospective study of vitamin E consumption and risk of coronary heart disease in women Stamper,M.J.;Hennekens,F.E.;Manson,J.E.;Colditz,G.A.;Rosner,B.;Willet,W.C.
  5. Am. J. Epidemiol. v.136 Dietary antioxidant intake and risk of coronary heart disease among men(abstract) Rimm,E.B.;Ascherio,A.;Willett,W.C.;Colditz,G.A.;Giovannucci,E.;Stamfer,M.J.
  6. Am. J. Clin. Nutr. v.62 no.SUP. Antioxidant vitamin-cardiovascular hypothesis is still promising but still unproven : The need for randomized rials Hennekens,C.H.;Gaziano,J.M.;Manson,J.E.;Buring,I.E.
  7. Environ. Health Perspect. v.64 Free-radical chemistry of cigarette smoke and its toxicological implications Church,D.F.;Pryor,W.A.
  8. Environ. Health Perspect. v.47 Electron-spin resonance study of mainstream and sidestream cigarette smoke : Nature of the free radicals in gas-phase smoke and in cigarette tar Pryor,W.A.;Prier,D.G.;Church,D.F.
  9. Atherosclerosis v.112 Vtamins E, C and lipid peroxidation in plasma and arterial tissue of smokers and non-smokers Mezzetti,A.;Lapenna,D.;Pierdomenico,S.D.;Calafiore,A.M.;Constantini,F.;Riario-Sforza,G.;Imbastaro,T.;Neri,M.;Caccurullo,F.
  10. Am. J. Clin. Nutr. v.53 Effect of smoking and vitamin E on blood antioxidant status Duthie,G.G.;Arthur,J.R.;Philip,W.;James,T.
  11. J. Am. Diet Assoc. v.95 Dietary supplementation with orange and carrot juice in cigarette smokers lowers oxidation products in copper-oxidised low-density lipoproteins Abby,M.;Noakes,M.;Nestel,P.J.
  12. Br. J. Nutr. v.73 no.4 Relationship between smoking and antioxidant status Faruque,M.O.;Khan,M.R.;Rahman,M.;Ahmed,F.
  13. Critical Review in Food and Nutrition v.35 no.1;2 Critical assessment of the epidemiological data concerning the impact of antioxidant nutrients on cancer and cardiovascular disease Machlin,L.J.
  14. Food and Nutrition v.35 no.1;2 Food and nutrient intake differences between smokers and nonsmokers in the SU Subar,A.F.;Harlen,L.C.;Mattson,M.E.
  15. Am. J. Public. Health v.80 Food and nutrient intake differences between smokers and nonsmokers in the SU Subar,A.F.;Harlen,L.C.;Mattson,M.E.
  16. Korean Journal of Epidemiology v.10 no.2 Epidemilologic characteristics of smoking in Korea Suh,I.
  17. Tobacco and Heath Association of an Antismoking Campaign
  18. Korean Journal of Epidemiology v.10 no.2 Smoking-attributable mortality among Korean adults Meng,K.H.
  19. Food items and serving size for food intake survey Institute of Food and Hygine
  20. Recommended Dietary Allowances for Koreans(6th Revision)
  21. Laboratory methods in clinical pathology Lee,S.Y.;Chong,Y.S.
  22. HPLC in food analysis(2nd ed.) Macrae,R.
  23. Am. J. Clin. Nutr. v.32 Simultaneous determination of alpha-tocopherol and retinol in plasma or red blood cell by high pressure liquid chromatography Bieri,G.;Tolliver,J.J.;Catignani,G.L.
  24. Modern Pathol. v.8 no.4 Blood parameters associated with atherogenic and thermogenic risk in smokers and nonsmokers with similar life-styles McKarns,S.C.;Smith,C.J.;Payne,V.M.;Doolittle,D.J.
  25. Am. J. Cardiol. v.77 no.4 Usefulness of antioxidant vitamins in suspected acute myocardial-infarction(the indian experiment of infarct survival-3) Singh,R.B.;Niaz,M.A.;Rastogi,S.S.;Rastogi,S.
  26. J. Hypertension v.5 no.SUP. Vitamin C deficiency and low linolenate intake associated with elevated blood pressure : The Kuopio ischaemic heart disease risk factor study Salonen,J.T.;Salonen,R.;Ihanainen,M.
  27. Am. J. Clin. Nutr. v.48 no.SUP. Blood pressure, dietary fats and antioxidant Salonen,J.T.;Salonen,R.;Ihanainen,M.
  28. J. Okla. State Med. Assoc. v.77 Effect of vitamin C on blood parameters of hypertensive subjects Koh,E.T.
  29. Archives of Biochemistry and Biophysics v.216 no.3 Effect of vitamin E, ascorbic acid and mannitol on alloxan-induced peroxidation in rats Dillard,C.J.;Kunert,K.J.;Tappel,A.L.
  30. J. Lipid Res. v.30 no.12 Antioxidant treatment of diabetic rats inhibits lipoprotein oxidation cytotoxicity Morel,D.W.;Chisolm,G.M.
  31. J. Biochem. Toxicol. v.11 no.3 Blood antioxidant status and urine sulfate and thiocyanate level in smokers Abou Sief,M.A.
  32. Int. J. Relat. Metab. Disord. v.20 no.11 Relationship of uric acid concentration to cardiovascular risk factors in young men Borona,E.;Targher,G.;Zenere,M.B.;Saggiani,F.
  33. Am. J. Clin. Nutr. v.60 Selenium status, fatty acids, antioxidant vitamins and aging : the Nove study Oliveri,O;Stanzial,a.M.;Girelli,D.;Trevisan,M.L,;Guarini,P.:Terzi,M.;Caffi,S.;Fontana,F.;Casaril,M.;Ferrari,S.;Corrocher,R.
  34. Modern Pathol. v.8 no.4 Blood parameters associated with atherogenic and thermogenic risk in smokers and nonsmokers with similar life-styles McKarns,S.C.;Smith,C.J.;Payne,V.M.;Doolittle,D.J.
  35. Am. J. Clin. Nutr. v.33 Dietary vitamin C supplementation and plasma vitamin E levels in humans Chrisley,B.M.
  36. European J. Clin. Nutr. v.48 no.9 Increase in oxidation resistance of atherogenic serum lipoproteins following antioxidant supplementation : A randomized double-blind placebo-controlled clinical trial Nyyssonen,K.;Pokkala,E.;Salonen,R.;Korpela,H.;Salonen,J.T.
  37. Am. J. Clin. Nutr. v.58 no.SUP. Antioxidant vitamins and low-density lipoprotein oxidation Abby,M.;Nestel,P.;Baghurst,P.A.
  38. The Korean Journal Nutrition v.29 no.1 Vitamine C intakes and serum levels in smoking college students Park,J.A.;Kang,M.H.
  39. Principles of nutritional assessment Gibson,R.S.