Influence of Cardiovascular Risk Factors on Serum Lipid Levels and Fatty Acids Composition in Middle-aged Men

중년 남성의 혈중지질농도 및 지방산조성에 영향을 미치는 요인 분석

  • 이인열 (중앙대학교 가정교육학과)
  • Published : 1998.04.01

Abstract

This study was performed to investigate the serum lipid levels and fatty acid composition in middle-aged men and the influence of cardiovscular risk factors on them. Data for dietary intake, anthropometry , blood pressure, and general environmental factors were obtained and their relationship to serum lipid levels and fatty acid composition were analyzed in 303 healthy male subjects with a mean age of 43.8$\pm$6.4 years from June 1 to 22 , 1995. The prevalence of obesity was 26.7% by BMI and 11.2% by WHR criteria . The percentage of hypertensive subjects were 13.5% and 22.4% by systolic and diastolic blood pressure, respectively. Retinol, calcium , and roboflavin intakes were lower than the RDA for Koreans. The ratio of carbohydrate intake to total calories of the subjects was 70%. Ratios of P/M and n-6/n-3 were 1.02/1.05/1.00 and 11.1/1, respectively. The percentage of subjects who had serum TG, TC, LDL-C leves beyond the normal range were 19.5% , 13.5% and 8.6% respectively. Palmitic comprised 26.4% of serum total fatty acids, linoleic acid 19.4% and oleic acid 16.4. The waist circumference and ration of carbohydrate intake were related positively to TG level. Serum cholesterol level had positive relations with waist circumference, DBP, sugar intake, and income. There were positive relationships between SFA and bone fishes and vegetable oil intakes, MUFA and DBP while a negative a negative relationship was observed between PUFA and animal fat intake. Serum n-6 fatty acid was related negatively to carbohydrate intake and hot taste preference. N-3 fatty acid was related positively to fish intake and negatively to egg intake. These results suggest that to maintain adequate serum lipid levels and fatty acid composition, sugar, animal fat, and carbohydrate intakes have to be reduced, while consumption of vegetable oil and fish must be increased. It is also essential to control abdominal fat accumulation and blood pressure.

Keywords

References

  1. Korean J. Nutr. v.29 no.4 Nutritional problems in Korea Lee,H.K.
  2. The Economic Planning Borad
  3. Korean J. Internal Medicine v.38 no.5 Risk factors for coronary artery disease J,D.S.
  4. Am. J. Epidemiol. v.119 no.5 Ten-tear of coronary heart disease in the honolulu heart program McGee,D.M.;Reed,D.M.;Yano,K.;Kagan,A.;Tillotson,J.
  5. Am. J. Clin. Nutr. v.45 Monounsaturated fatty acids, plasma cholesterol, and coronary heart disease Grundy,S.M.
  6. Korean J. Nutr. v.30 no.4 Effect of high carbohydrate intakes on the obesity index, blood pressure, and blood lipid levels in patients with cardiovascular disease Lee Seung Min;Ahn Hyang Sook;Lee Lilha
  7. Korean J. Medicine v.18 no.4 Research about Korean highlipidemia(I) Son,Y.S.
  8. Korean J. Medicine v.18 no.5 Research about Korean highlipidemia(II) Son,Y.S.
  9. J. Chron. Dis. v.31 Relationship of blood pressure, serum cholesterol, smoking habit, relative weight and ecg abnormalities to incidence of major coronary events Pooling Project Resource Group
  10. Atherosclerosis v.42 Plasma lipids and lipoproteins in Japanese male patients with coronary artery disease and in their relatives Hitoshi,K.;Imamura,Y.;Hamada,M.;Kokubu,T.
  11. Nutr. Rev. v.50 no.4 Marine oils and their effects Drevon,C.A.
  12. J. Lipid Res. v.30 Fish oils and plasma lipid and lipoprotein metabolism in humans : a critical review Harris,W.S.
  13. Athrosclerosis v.83 A possible contribution of decrease in free fatty acids to low triglyceride levels after diets supplemented with n-6 and n-3 polyunsaturated fatty acids Singer,P.;Wirth,M.;Berger,I.
  14. Clin. Chem. v.18 Estimation of concentration of low density lipoprotein cholesterol in plasma without use of the preparative ultracentrifuge Friedewald,W.T.;Levy,R.I.;Fedre,D.S.
  15. J. Biol. Chem. v.226 A simple method for the isolation and purification of total lipids from animal tissues Folch,J.;Lees,M.;Sloane-Stanley,G.H.
  16. J. Lip. Res. v.5 Preparation of fatty acid methyl esters and dimethylacetals from lipids with boron fluoride-methanol Morrison,W.R.;Smith,L.M.
  17. Seoul Statistical Year Book
  18. Korean J. Nutr. v.28 no.1 A study on the status of antioxidant nutrients and lipid in the middle-aged Korean men living in Taegu Cho,S.H.;Lee,O.J.;Im,J.G.;Choi,Y.S.;Ryu,R.N.;Park,W.H.
  19. Korean J. Nutr. v.26 no.9 The relationships obese index and major risk factors in patients with cardiovascular disease Ahn,H.S.;Lee,L.H.
  20. Korean J. Nutr. v.24 no.1 Relationship of habitual alcohol consumption to the nutritional status in middle aged men Lee,S.H.;Kim,W.Y.
  21. J. Asian Reg. Asso. Home Ec. v.3 Relationship between dietary lipids patterns and major risk factors of cardiovascular disease in hypertensive patients Jung,I.K.;Lee,L.H.
  22. Recommended dietary allowances for Koreans(6th revision)
  23. Korean J. Nutr. v.27 no.2 Relationship between dietary fatty acids, plasma lipids, and fatty acid compositions of plasma and RBC in young Korean females Kim,Y.H.;Paik,H.Y.
  24. Euro. J. Clin. Nutr. v.43 Comparison between habitual intake of polyunsaturated fatty acids and their concentrations in serum lipid fractions Kester,A.C.;Houwelingen,A.D.M.;Kromhout,D.;Hornstra,G.
  25. Am. J. Clin. Nutr. v.53 Lipid, lipoprotein, and hemostatic effects of fish vs fish-oil n-3 fatty acids on midly hyperlipidemic males Cobiac,L.;Clifton,P.M.;Nestel,P.;Belling,G.B.
  26. Lancet v.22 Eicosapentaenoic acid and platelet function in Japanese Hirai,A.;Hamazaki,T.;Terano,T.
  27. Annal Internal Med. v.62 no.6 Dietary sugar in the production of hyperglyceridemia Kuo,P.T.;Basset,D.R.
  28. Korean J. Nutr. v.26 no.3 Influence of total abdominal fat accumulation on serum lipids and lipoproteins in Korean middle-aged men Huh,K.B.;Lee,J.H.;Paik,I.K.;,Ahn,K.J.;Jung,Y.S.;Kim,M.J.;Lee,Y.H.;Lee,Y.J.
  29. Metabolism v.36 Contribution of intra-abdominal fat accumulation to the impairment of glucose and lipid metabolism in human obesity Fujioka,S.;Matsuzawa,Y.;Tarui,S.
  30. Br. Med. J. v.289 Distributional of adipose tissue and risk cardiovascular disease and death Lapidus,L.;Bengtsson,C.;Larsson,B.;Sjostrom,L.
  31. Master's Thesis, Yonsei University A study on serum lipids of healthy Korean adults Synn,H.A.
  32. J. Clin. Invest. v.74 Suppression by diets rich in fish oil of very low density lipoprotein production in man Nestel,P.J.;Conner,W.E.;Reardon,M.F.;Boston,R.
  33. Am. J. Clin. Nutr. v.34 The effect of various intakes of w-3 fatty acids on the blood lipid composition in healthy human subjects Bronsgeest-Schoute,H.C.;Gent,C.M.;Ruiter,A.