A Study on the Effect of Chitin, Chitosan and Dithiocarbamate Chitosan on the Cadmium Accumulation in Liver of Rats

Chitin 및 Chitosan이 생체내 카드뮴 축적에 미치는 영향 -Chitin, Chitosan 및 Dithiocarbamate Chitosan이 흰쥐 간내 카드뮴 축적에 미치는 영향-

When rats are exposed to cadmium in their diet, the cadmium accumulates in the liver. This study was carried out to investigate the effect of chitin, chitosan and dithiocarbamate chitosan on the cadmium accumulation in liver of rats. For this experiment, 10 male Sprague-Dawley were used. The experimental groups were divided into four independent groups which were one control group and three experimental groups by cadmium alone treatment or chitin, chitosan and dithiocarbamate chitosan with cadmium. In order to investigate the eliminative effect of chitin, chitosan and dithiocarbamate chitosan on the cadmium accumulation in liver of rats, the cadmium concentration, the metallothionein level and the enzyme activitys were measured. The results obtained revealed the eliminative effect of cadmium in liver of rats by chitin, chitosan and dithiocarbamate chitosan. The effect of chitin on the cadmium elimination was less than that of chitosan and dithiocarbamate chitosan. Also it shows that the eliminative effect of cadmium by dithiocarbamate chitosan was the highest.