Journal of Nutrition and Health

The Korean Nutrition Society (한국영양학회)
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The Effect of Iron Supplementation on the Hematological Iron Status and Pb and CD Levels in Erythrocyte, Hair and Urine of Subjects With Suboptimal Iron Status

철분의 구강투여가 철분부족 아동의 혈중철분지표 및 적혈구, 소변, 머리카락의 납 과 카드뮴 수준변화에 미치는 영향

  • 손숙미 (가톨릭대학교 식품영양학과) ;
  • 정혜영 (가톨릭대학교 식품영양학과)
  • Published : 1998.09.01
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Abstract

The effect of oral iron supplementation was assessed on blood iron levels and Pb and Cd levels in erythrocytes, hair and urine of 101 Puchon 5th grade school children with suboptimal iron status. Treatment with 25mg of elemental iron per day for 8weeks resulted in a significant increase in the intake of most nutrients in addition to iron. Iron supplementation resulted in significant improvements in hemoglobin, MU, MCH, MCHC, serum ferritin, serum iron, TIBC, and transferrin saturation of subjects(p<0.05 - p<0.01) and cocomitantly lowered Pb and Cd levels in erythrocytes, hair, and urine(p<0.01). Regression analysis showed that only iron intake contributed to significant increases in hemoglobin and serum ferritin. It seems that 25mg of iron supplementation is safe and adequate to improve iron status in school children with suboptimal iron status and it also has the benefit of alleviating Pb and Cd status. (Korean J Nutrition 31(7) : 1165-1173, 1998)

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References

  1. Nutrition during the life cycle Mo,S.;Chio,C.;Koo,J.;Lee,J.W.
  2. Korean J Nutr v.23 no.7 Nutrition survey of children attending an elementary school without a school lunch program, in a low income group of seoul 1. A study on anthropometry and biochemical test Chung,S.J.;Kim,C.I.;Lee,E.W.;Mo,S.
  3. Korean J Community Nutr v.2 no.3 Nutritional status of 5th grade school children residing in low-income area of Puchon City Son,S.M.;Yang,C.S.
  4. Fundamental Nutrition Lee,K.Y.;Moon,S.J.
  5. Env Res v.25 Aerometric hair trace metal content in learning disabled children Ely,D.L.;Mostadi,R.A.;Woebkenberg,N.;Worstell,D.
  6. J Lab Clin Med v.92 no.4 Effects of iron on the absorption and retention of lead Bartion,J.C.;Conrad,M.E.;Nuby,S.;Harrison,L.
  7. Gastroenterology v.74 no.5 Increased dietary cadmium absorption in mice and human subjects with iron deficiency Peter,R.F.;Jenny,S.M.;James,H.
  8. Federation Proc v.35 Aspects of biochemical toxicology of cadmium Singhal,R.L.;Merali,Z.H.
  9. J Pediatr v.18 Chronic lead poisoning George,J.C.;Walter,E.A.
  10. J Child Psychol Psychiatry v.30 Blood lead levels and children's behavior Thomson,G.;Raab,G.M.;Hepburm,W.S.;Hunter,R.
  11. Korean J Community Nutr v.3 no.2 The difference of iron, lead and cadmium concentration of blood, urine and hair in children with suboptimal iron status Son,S.M.;Yang,C.S.
  12. 도시가계연보 통계청
  13. Geriatrics v.38 no.8 Common anemias : A practical guide to diagnosis and management Stuckey,W.J.
  14. Blood v.80 no.3 Developmnet of iron chelating agents for clinical use Gray,M.B.
  15. Nutrition in aging(2th) Eleanor,D.S.
  16. Hematology of infancy and childhood(3rd ed) Iron deficiency and related nutritional anemias Dallman,P.R.
  17. Am J Clin Nutr v.47 Iron supplementation and physical growth of rural Indonesian children Chwang,L.C.;Soemantri,A.G.;Pollitt,E.
  18. Recommended dietary Allowance for Koreans(Sixth Revision) The Korean Nutri tion society
  19. Clinical laboratory method Bauer,J.D.
  20. Textbook of clinical chemistry Tietz,N.W.
  21. J Clin v.25 An immunoradiometric assay for ferritin in the serum of normal subjects and patients with iron deficiency and iron overload Addison,G.M.;Beamish,M.R.;Hales,C.N.;Hodgkins,H.;Jacobs,A.;Llewellin,P.
  22. Clinical laboratory method Bauer,J,D.
  23. Blood v.40 Erythrocyte protoporphyrin Langer,E.E.;Haining,R.G.;Labbe,R.F.;Jacobs,P.;Crosby,E.F.;Finch,C.A.
  24. microanalysis of erythrocyte protoporphyrin levles by spectrofluorome ter in the detection of chronic lead intoxication in the subclinical range v.8 Studies in lead posioning 1. Sassa,S.;Granick,J.L.;Kappas,A.;Levere,R.D.
  25. J Lab & Clin Med v.45 no.1 A rapid procedure for the determination of lead in blood or urine in the presence of organic chelating agents Besman,S.P.;Lagne,E.C.Jr.
  26. J Aut Develop Disorders v.12 no.1 Minerals in the hair and nutrient intake of autistic children Sheaer,T.R.;Larson,K.;Neuschwander,J.;Gedre,B.
  27. Clin Chem v.27 no.6 Comparison of concentrations of some trace, bulk, and toxic metals in the hair of normal and dyslexic children Capel,I.D.;Pinnock,M.H.;Dorrell,H.M.;William,D.C.;Grant,E.C.
  28. Nutritional anemias, WHO technical report, series 503 World Health Organization. Group of Experts.
  29. European Journal of Clinical Nutrition v.44 Bioavailability of daily low dose iron supplements in menstruating women with low iron stores Stenberg,V.;Reinskou,T.;Trygg,K.
  30. J Nutr v.109 Effect of dietary supplementation of iron and ascorbic acid on lead toxicity in rats Suzuki,T.;Yoshida,A.
  31. Gastroenterol v.74 Factors affecting the absorption and excretion of lead in the rat Conrad,M.E.;Barton,J.
  32. J Lab Clin Med v.92 no.4 Effects of iron on the absorption and retention of lead Barton,J.C.;Conrad,M.E.;Nuby,S.;Harrison,L.
  33. Arch Environ Health v.15 An International Study of Normal levels of lead in blood and urine Goldwater,L.J.;Hoover,A.W.
  34. Pediatr Clinics of North Amer v.17 no.3 Po+soning due to heavy metals Chisolm,J.J.
  35. Am J Clin Nutr v.31 Long-term effectiveness of dietary iron and ascorbic acid in the prevention and cure of cadmium toxicity in rats Suzuki,T.;Yoshida,A.
  36. Alan R Liss Cadmium toxicity in humans. Essential and toxic trace elements in human health and disease Smith,J.C.;Kench,J.E.
  37. Cadmium in the environment. chem. Friberg,L.;Piscator,M.;Nordberg,G.