Toxicological Research
- Volume 14 Issue 2
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- Pages.237-248
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- 1998
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- 1976-8257(pISSN)
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- 2234-2753(eISSN)
Acute and Subacute Toxicity of New Woohwangchungsimwon in Rats
랫드에서 신우황청심원의 급성 및 아급성독성시험
Abstract
The acute and subacute toxicity of New Woohwangchungsimwon(NWCH) which was used l-muscone as substitutive material of musk were investigated in S.D. rats. In intraperitoneal acute toxicity test. rats(Sprague-Dawley, SPF) were injected intraperitoneally with dosages of 0, 540, 750, 1,070, 1.500 and 3,000 mg/kg. Body weights were significantly decreased at 540 mg/kg dose group in both sexes and abnormal autopsy findings were founded in both sexes at all treated groups. Intraperitoneal