Toxicological Research
- Volume 14 Issue 2
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- Pages.261-271
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- 1998
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- 1976-8257(pISSN)
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- 2234-2753(eISSN)
Acute and Subacute Toxicity Studies of New Wonbangwoohwangchungsimwon in Rats
랫드에서 신원방우황청심원의 급성 및 아급성독성시험
Abstract
The acute and subacute toxicity of New Wonbangwoohwangchungsimwon (NSCH) which was used l-muscone as substitutive material of musk were investigated in S.D. rats. In intraperitoneal acute toxicity test, rats were injected intraperitoneally with five dosages of 0, 500, 710, 1,000, 1,410 and 2,000 mg/kg. Body weights were significantly decreased at 500 and 710 mg/kg dose group in male and abnormal autopsy findings were founded in both sexes at all dose. Intraperitoneal