Toxicological Research
- 제14권4호
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- Pages.587-594
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- 1998
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- 1976-8257(pISSN)
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- 2234-2753(eISSN)
Comparison Between TCDD and 3MC Action on CYP1A1 Expression and EROD Activity in the Isolated Perfused Female Rat Liver
- Ahn, Mee R. (College of Pharmacy, Ewha Womans University) ;
- Sheen, Yhun Y. (College of Pharmacy, Ewha Womans University)
- 발행 : 1998.12.01
초록
In order to understand the mechanism if the regulation of CYP 1A1 gene expression and ethoxyresorufin deethylase (EROD) activity in ex vivo system, we have studied the action of TCDD and 3MC in the isolated perfused female rat liver. CYP1A1 mRNA level and EROD activity were measured in rat liver that was isolated and perfused with various chemicals such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), 3-methylcholanthrene (3MC), 17