Clinical and Experimental Reproductive Medicine

The Korean Society for Reproductive Medicine (대한생식의학회)
권호 표지

A Case of Successful Pregnancy in Patient with Recurrent Spontaneous Abortion by Preimplantation Genetic Diagnosis Following IVF-ET

염색체 이상에 의한 반복 유산 환자에서 체외수정시술 및 착상전 유전진단을 통한 임신 성공 1례

  • Jeong, Jin-Seok (Department of Obstetrics and Gynecology, College of Medicine, University of Ulsan, Asan Medical Center) ;
  • Yeon, Gyu-Sun (Department of Obstetrics and Gynecology, College of Medicine, University of Ulsan, Asan Medical Center) ;
  • Chae, Hee-Dong (Department of Obstetrics and Gynecology, College of Medicine, University of Ulsan, Asan Medical Center) ;
  • Cheon, Yong-Pil (Department of Obstetrics and Gynecology, College of Medicine, University of Ulsan, Asan Medical Center) ;
  • Kim, Chung-Hoon (Department of Obstetrics and Gynecology, College of Medicine, University of Ulsan, Asan Medical Center) ;
  • Kang, Byung-Moon (Department of Obstetrics and Gynecology, College of Medicine, University of Ulsan, Asan Medical Center) ;
  • Chang, Yoon-Seok (Department of Obstetrics and Gynecology, College of Medicine, University of Ulsan, Asan Medical Center) ;
  • Mok, Jung-Eun (Department of Obstetrics and Gynecology, College of Medicine, University of Ulsan, Asan Medical Center)
  • 정진석 (울산대학교 의과대학 서울중앙병원 산부인과학교실) ;
  • 연규선 (울산대학교 의과대학 서울중앙병원 산부인과학교실) ;
  • 채희동 (울산대학교 의과대학 서울중앙병원 산부인과학교실) ;
  • 전용필 (울산대학교 의과대학 서울중앙병원 산부인과학교실) ;
  • 김정훈 (울산대학교 의과대학 서울중앙병원 산부인과학교실) ;
  • 강병문 (울산대학교 의과대학 서울중앙병원 산부인과학교실) ;
  • 장윤석 (울산대학교 의과대학 서울중앙병원 산부인과학교실) ;
  • 목정은 (울산대학교 의과대학 서울중앙병원 산부인과학교실)
  • Published : 1998.06.30
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Abstract

It was reported that the etiologies of recurrent spontaneous abortion are immunologic factors, endocrinologic problems, anatomical abnormalities, genetic abnormalities, infection, and unexplained factors. Among those etiologic factors, genetic abnormalities occur in about 5% of the couples who experience recurrent spontaneous abortions, and most common parental chromosomal abnormality contributing to recurrent abortion is balanced translocation. The advent of in vitro fertilization (IVF), the development of skills associated with the handling of human embryo, and an explosion of knowledge in molecular biology have opened the possibility of early diagnosis of genetic disease in preimplantation embryos. Therefore preimplantation genetic diagnosis (PGD) is indicated for couples, infertile or not, at risk of transmitting a genetic disease. A case of successful pregnancy and term delivery by PGD using fluorescence in situ hybridization (FISH) technique in patient with recurrent spontaneous abortion due to balanced translocation is presented with brief review of literatures.

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