Archives of Pharmacal Research

The Pharmaceutical Society of Korea (대한약학회)
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Growth Inhibitory Activities of Kalopanaxsaponins A and I against Human Pathogenic Fungi

  • Kim, Dong-Wook (Research Institute for Wakan-Yaku, Toyama Medical and Pharmaceutical University) ;
  • Bang, Kyu-Ho (Department of Microbiology, Chungnam National University) ;
  • Rhee, Young-ha (Department of Microbiology, Chungnam National University) ;
  • Lee, Kyung-Tae (College of Pharmacy, Kyung-Hee University) ;
  • Park, Hee-Juhn (Department of Botanical Resources, Sangji University)
  • Published : 1998.12.01
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Abstract

Antifungal activities of the compounds isolated from Kalopanax pictus against representative fungi of dermatomycosis were investigated using paper disc diffusion method. It was found that kalopanaxsaponins A and I were effective in inhibiting the growth of Candida albicans KCTC 1940 and Cryptococcus neoformans KCTC 7224 with minimum inhibitory concentration(MIC) of 25${\mu}g$/ml. It showed that antifungal activity of both compounds have strong selectivity against the fungi of dermatomycosis.

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