Archives of Pharmacal Research
- Volume 21 Issue 6
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- Pages.753-758
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- 1998
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- 0253-6269(pISSN)
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- 1976-3786(eISSN)
Synthesis and Biological Evaluation of Novel 2-[Substituted acetly]-amino-5-alkyl]-amino-5-alkyl-1,3,4-thiadiazoles
- Shakya, Ashok K. (Clinical Pharmacology & Pharmacokinetics Ranbaxy Research Laboratories) ;
- Mishra, Pradeep (Division of Medicinal Chemistry, Department of Pharmaceutical Sciences, Dr. Harisingh Gour Vishwavidyalaya [Formerly University of Saugor]) ;
- Patnaik, G.K. (Clinical Pharmacology & Pharmacokinetics Ranbaxy Research Laboratories) ;
- Shukla, Rakesh (Clinical Pharmacology & Pharmacokinetics Ranbaxy Research Laboratories) ;
- Srimal, R.C. (Division of Pharmacology Central Drug Research Institute)
- Published : 1998.12.01
Abstract
Sixteen novel 2-substituted acetyl amino-5-alkyl-1,3,4-thiadiazol were synthesized and screened for their pharmacological activities. A few of the compounds namely 11, 12 and 16 showed anti-inflammatory activities comparable to phenylbutazone. Compound 12 also showed significan non-specific spasmolytic activity. Diuretic activity of compound 15 at a dose level of 90mg/kg p.o. was two fold higher compared to 50mg/kg p.o. of furosemide. Comparable diuresis was aso produced by compounds 9, 10, and 16.
Keywords
- 2-[Substituted acetyl]-amino-5-alkyl-1,3,4-thiadiazoles;
- 2-[Substituted-ethanamido]-5-alkyl-1,3,4-thiadiazoles;
- 1,3,4-Thiadiazole;
- Diruetic;
- Anti-inflammatory agent