YAKHAK HOEJI (약학회지)

The Pharmaceutical Society of Korea (대한약학회)
권호 표지

Screening of the Antibacterial Activity of Natural Products aganist Propionibacterium acnes

Propionibacterium acnes에 대한 천연물의 항균효과 검색

  • 최승만 ((주)LG화학 생활과학연구소) ;
  • 김민주 ((주)LG화학 생활과학연구소) ;
  • 최영호 ((주)LG화학 생활과학연구소) ;
  • 안호정 ((주)LG화학 생활과학연구소) ;
  • 윤여표 (충북대학교 약학대학)
  • Published : 1998.02.01
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Abstract

Propionibacterium acnes is the pharmacological target site of antiacne drugs. We have examined the antiacne activity of ninety seven natural products which have been used as Korean traditional medicines in various skin disorders. The antibacterial activity of extracts from the natural products were evaluated against P. acnes ATCC 9616 by disc method. Twelve natural products showed the potent antibacterial activity against P. acnes, and were, selected for the minimal inhibitory concentration(MC) against P. acnes. MICs of nine extracts were below 0.3% (w/v) and Sophora flavescens showed the most potent activity with a MIC of less than 0.008%(w/v) against P. acnes. Thus, the results suggest that nine natural products including S. flavescens can be developed as sources of promising potent antiacne agents.

Keywords

References

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