Korean Journal of Veterinary Research (대한수의학회지)
- Volume 38 Issue 3
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- Pages.606-613
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- 1998
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- 2466-1384(pISSN)
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- 2466-1392(eISSN)
Genotoxicity of cadmium chloride in Salmonella typhimurium and rat liver epithelial cells
카드뮴의 Salmonella typhimurium 변이균주 및 랫드 간장 상피세포에서의 유전독성
- Jeong, Sang-hee (National Veterinary Research and Quarantine Services, MAF) ;
- Cho, Myung-haing (College of Veterinary Medcine, Seoul National University) ;
- Cho, Joon-hyoung (National Veterinary Research and Quarantine Services, MAF)
- Received : 1998.08.25
- Published : 1998.09.25
Abstract
Cadmium is one of the well-known environmental toxicants and induces cancer in rodents and human, but its carcinogenic mechanism has not been well demonstrated until now. Genotoxic effects of cadmium in Salmonella typhimurium TA98, TA100 and TA1535/pSK1002 or in WB-F344 rat liver epithelial cells were investigated to elucidate the tumor initiating effects of cadmium. TA98, TA100 and TA1535/pSK1002 tester strains were used to detect frameshift mutation, base-pair mutation and SOS repair response, respectively, in Salmonella mutation test. Reverse mutations from histidine to