BMB Reports
- 제31권6호
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- Pages.560-564
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- 1998
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- 1976-670X(eISSN)
Cytotoxic and Apoptotic Activites of Echinomycin Derivative (Echinomycin-7) on P388 Murine Leukemia Cells
- Jeon, Hyang (Department of Medical Technology, College of Health Science, Yonsei University) ;
- Kim, Sung-Su (Department of Medical Technology, College of Health Science, Yonsei University) ;
- Kim, Yoon-Suk (Department of Medical Technology, College of Health Science, Yonsei University) ;
- Park, Yil-Sung (Department of Chemistry, KAIST) ;
- Kim, Yong-Hae (Department of Chemistry, KAIST) ;
- Choi, Sun-Ju (Department of Microbiology, Wonju College of Medicine, Yonsei University) ;
- Kim, Soo-Kie (Department of Microbiology, Wonju College of Medicine, Yonsei University) ;
- Kim, Tae-Ue (Department of Medical Technology, College of Health Science, Yonsei University)
- 투고 : 1998.06.22
- 심사 : 1998.08.01
- 발행 : 1998.11.30
초록
Echinomycin-7 is an echinomycin derivative, Smethylated sulfonium perchlorate of echinomycin. We studied the in vitro cytotoxicity and in vivo antitumor activity of echinomycin-7 against P388 leukemia cells and compared the results with echinomycin. With respect to the cytotoxic effects, echinomycin-7 had cell line-dependent