생약학회지 (Korean Journal of Pharmacognosy)
- 제30권1호
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- Pages.12-17
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- 1999
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- 0253-3073(pISSN)
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- 2288-9299(eISSN)
영계출감탕의 간독성에 미치는 영향
Effects of Youngkaechulgamtang on Hepatotoxicity
- Kim, Tae-Hee (College of Pharmacy, Sookmyung Women's University) ;
- Yang, Ki-Sook (College of Pharmacy, Sookmyung Women's University) ;
- Park, Seung-Ah (College of Pharmacy, Sookmyung Women's University)
- 발행 : 1999.03.30
초록
The youngkaechulgamtang (Y) composed of four herb drugs, including Hoelen (H). Cinnamomi Ramulus (C). Atractylodis Rhizoma Alba (A) and Glycyrrhizae Radix (G). In oriental medicine literatures, Youngkaechulgamtang is described to be effective in headache, inflammation, uremia, gastritis, diarrhea and hypertension. To estimate the clinical effectiveness of Youngkaechulgamtang, several pharmacological experiments were carried out. The results are summerized as follows; On acetaminophen-induced hepatotoxicity, C+A, Y-G, Y-H, MIX and Y showed the significant elevation of glutathione-S-transferase. But, C+A, Y-G, Y-H, MIX and Y showed the significant suppression of serum aminotransferases. On ANIT-induced cholestasis, U (Ursodesoxycholic acid 50 mg/kg)+