Korean Journal of Pharmacognosy (생약학회지)

The Korean Society of Pharmacognosy (한국생약학회)
권호 표지

Hypoglycemic Effect of Mulberry Leaves with Anaerobic Treatment in Alloxan-induced Diabetic Mice

혐기처리한 뽕잎의 혈당강하 효과

  • Ryu, Kang-Sun (Department of Sericulture and Entomology, National Institute of Agriculture Science and Technology, RDA) ;
  • Lee, Won-Chu (Department of Sericulture and Entomology, National Institute of Agriculture Science and Technology, RDA) ;
  • Ku, Hyun-Ok (National Veternary Research and Quaranting Service) ;
  • Lee, Hoi-Seon (Division of Applied Biology and Chemistry, College of Agriculture and Life Science, Seoul National University) ;
  • Lee, Kang-Ro (College of Pharmacy, Sung Kyun Kwan University) ;
  • Kim, Sun-Yeou (Department of Sericulture and Entomology, National Institute of Agriculture Science and Technology, RDA)
  • 류강선 (농촌진흥청 농업과학기술원 잠사곤충부) ;
  • 이완주 (농촌진흥청 농업과학기술원 잠사곤충부) ;
  • 구현옥 (국립수의검역원) ;
  • 이회선 (서울대학교 농업생명과학대학 응용생물화학부) ;
  • 이강노 (성균관대학교 약학부) ;
  • 김선여 (농촌진흥청 농업과학기술원 잠사곤충부)
  • Published : 1999.06.30
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Abstract

The hypoglycemic effect of mulberry leaves using alloxan-induced diabetic mice was investigated. The hypoglycemic effect of mulberry leaves was significantly affected with anaerobic incubation up to for 6 hrs. The body weight of mice treated with 20% anaerobic conditioned mulberry leaves was higher than that in the control group. Mulberry leaves which were treated with anaerobic condition significantly decreased blood glucose level in alloxan-induced type I diabetes mice. Furthermore, glucose tolerance was significantly recovered by feeding mulberry leaves anaerobically treated. Pathological analysis revealed that the disappearance of insulin-secreting beta-cells in the islets of Langerhans from the alloxan induced diabetic mice was strongly inhibited in the mulberry leaves feeding group. The content of 1-deoxynojirimycin increased up to 5% in detached mulberry leaves incubated under nitrogen gas for 6 hrs. Nevertheless, it is not clear whether the synthesis of 1-deoxynojirimycin is increased or the degradation of it is decreased. Overall, results obtained from this study indicate that the hypoglycemic effect was increased by the mulberry leaves with anaerobic treatment.

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