Journal of Pharmaceutical Investigation
- Volume 29 Issue 2
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- Pages.105-109
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- 1999
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- 2093-5552(pISSN)
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- 2093-6214(eISSN)
In Vitro Controlled Release of Piracetam with Coated Ion-Exchange Resin
이온교환수지를 이용한 피라세탐의 in vitro 방출조절
- Hwang, Young-Sook (College of Pharmacy, Kyung Hee University) ;
-
Lee, Kyung-Tae
(College of Pharmacy, Kyung Hee University)
;
- Seo, Seong-Hoon (College of Pharmacy, Kyung Hee University)
- Published : 1999.06.20
Abstract
The sustained release of piracetam by complexation with ion exchange resin was prepared. The complex was coated with Eudragit RS100 and their releases in vitro were conducted with various different kinds of medium solution. Dissolution rate increased as ionic strength, acidity and drug concentrations increased and reached its maximal plateau concentration within 5 min. Based on these data, The controlled release of piracetam using ion-exchange piracetam complex coated with Eudragit RS100 could be available.