Journal of Pharmaceutical Investigation
- Volume 29 Issue 2
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- Pages.137-143
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- 1999
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- 2093-5552(pISSN)
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- 2093-6214(eISSN)
Anti-inflammatory Activity of Ketoprofen Soft Hydrogel
케토푸로펜 소프트 히드로겔의 항염증효과
- Lee, Eun-Kyung (College of Pharmacy, Pusan National University) ;
- Shin, Young-Hee (College of Pharmacy, Kyungsung University) ;
- Lee, Chi-Ho (College of Pharmacy, Pusan National University)
- Published : 1999.06.20
Abstract
Ketoprofen together with various permeation enhancers was incorporated into a novel soft hydrogel which is semi-solid in a container and to form a thin film within a few minutes after applying on the skin. The effect of various enhancers on the skin permeation of ketoprofen from a soft hydrogel was investigated using in vitro and in vivo method. In vitro rat skin permeation of ketoprofen from soft hydrogel was conducted using modified Keshary-Chien diffusion cells. In vivo ketoprofen absorption was also investigated in rats, and the results were compared with that of commercial products. Anti-inflammatory activities were determined using carrageenan-induced paw edema method and adjuvant-induced arthritis method in rats. The anti-inflammatory activity of ketoprofen soft hydrogel formulation with that of commercial products were compared. In vitro as well as in vivo studies showed that
Keywords
- Soft hydrogel;
- Ketoprofen, Permeation enhancer;
- Percutaneous absorption;
- Anti-inflammatory activity;
- Carrageenan-induced paw edema;
- Adjuvant-induced arthritis