Journal of Pharmaceutical Investigation

The Korean Society of Pharmaceutical Sciences and Technology (한국약제학회)
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Preparation and Evaluation of Phenylpropanolamine HCI by Complexation with Cation Exchange Resin

양이온교환수지복합체에 의한 페닐프로판올아민염산염의 제조 및 평가

  • Kim, In-Kyu (Korea Food and Drug Administration) ;
  • Lee, Kyung-Tae (College of Pharmacy and Kyunghee East-Weat Pharmaceutical Research institute, Kyung Hee University) ;
  • Seo, Seong-Hoon (College of Pharmacy and Kyunghee East-Weat Pharmaceutical Research institute, Kyung Hee University) ;
  • Kim, Chong-Kook (College of Pharmacy, Seoul National University) ;
  • Kim, Dong-Hyun (College of Pharmacy and Kyunghee East-Weat Pharmaceutical Research institute, Kyung Hee University) ;
  • Rho, Young-Soo (College of Pharmacy and Kyunghee East-Weat Pharmaceutical Research institute, Kyung Hee University)
  • 김인규 (식품의약품안전청) ;
  • 이경태 (경희대학교 약학대학/동서약학연구소) ;
  • 서성훈 (경희대학교 약학대학/동서약학연구소) ;
  • 김종국 (서울대학교 약학대학) ;
  • 김동현 (경희대학교 약학대학/동서약학연구소) ;
  • 노영수 (경희대학교 약학대학/동서약학연구소)
  • Published : 1999.12.20
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Abstract

This study was prepared to develop the sustained release dosage form of phenylpropanolamine hydrochloride (PPA) by complexation with cation exchange resin(CER). The PPA-CER complex was confirmed by differential scanning calorimetry(DSC) thennogram, indicating a relative shift of an endometric peak of PPA to higher temperature. The loading efficiency was increased as the amount of PPA was increased as well as the time of fractional exchange was advanced as the temperatures were increased. Loading efficiency, fractional exchange, reaction rate constant and activation energy were highly dependent on the temperature and drug : resin ratio. The optimal ratio of PPA and resin was estimated to be 10: 10 for the sustained release.

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