The Journal of Korean Medicine (대한한의학회지)

The Society of Korean Medicine (대한한의학회)
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An Experiment of the Purgative Action of Rhei Rhizoma and Chungpesagan-tang

청폐사간탕(淸肺瀉肝湯)과 대황(大黃)의 사하효과(瀉下效果)에 관한 실험적 연구

  • Kim, Jung-Jin (Dept. of Circulatory Internal Medicine, College of Oriental Medicine, Kyung Hee University) ;
  • Park, Eun-Kyung (College of Pharmacy, Kyung Hee University) ;
  • Bae, Hyung-Sup (Dept. of Circulatory Internal Medicine, College of Oriental Medicine, Kyung Hee University) ;
  • Moon, Sang-Kwan (Dept. of Circulatory Internal Medicine, College of Oriental Medicine, Kyung Hee University) ;
  • Kim, Young-Suk (Dept. of Circulatory Internal Medicine, College of Oriental Medicine, Kyung Hee University) ;
  • Lee, Kyung-Sup (Dept. of Circulatory Internal Medicine, College of Oriental Medicine, Kyung Hee University) ;
  • Kim, Dong-Hyun (College of Pharmacy, Kyung Hee University) ;
  • Cho, Ki-Ho (Dept. of Circulatory Internal Medicine, College of Oriental Medicine, Kyung Hee University)
  • 김정진 (경희대학교 한의과대학 심계내과학교실) ;
  • 박은경 (경희대학교 약학대학) ;
  • 배형섭 (경희대학교 한의과대학 심계내과학교실) ;
  • 문상관 (경희대학교 한의과대학 심계내과학교실) ;
  • 김영석 (경희대학교 한의과대학 심계내과학교실) ;
  • 이경섭 (경희대학교 한의과대학 심계내과학교실) ;
  • 김동현 (경희대학교 약학대학) ;
  • 조기호 (경희대학교 한의과대학 심계내과학교실)
  • Published : 1999.09.30
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Abstract

Objectives: This study was conducted to analyze scientifically the purgative action of Chungpesagan-tang, which was widely used for stroke In Oriental Medicine. Methods: The contents of sennoside A on the water-extraction of Rhei Rhizoma, the transforming activity of sennoside A to rheinanthrone by human intestinal bacteria, and the anti-costive activity of Chungpesagan-tang, Rhei Rhizoma and Yuldahanso-tang on mice were investigated. Results: Rhei Rhizoma (Rheum palmatum, from China) had dose-dependent potent purgative action. Chungpesagan-tang containing this Rhei Rhizoma had more potent purgative action than Rhei Rhizoma only. However, Korean cultivated Rhei Rhizoma (Rheum undulatum) and Chungpesagan-tang containing this Korean cultivated Rhei Rhizoma had no purgative action. Conclusions: These results suggest that Chungpesagan-tang polyprescription should be considered to enhance the purgative action of Rhei Rhizoma.

Keywords

References

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