Archives of Pharmacal Research

The Pharmaceutical Society of Korea (대한약학회)
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A New Cytotoxic Acyclic Diterpene from Carpesium divaricatum

  • Zee, Ok-Pyo (Natural Products Laboratory, College of Pharmacy, Sung Kyun Kwan University) ;
  • Kim, Dae-Keun (Natural Products Laboratory, College of Pharmacy, Woosuk University) ;
  • Choi, Sang-Un (Pharmaceutical Screening Team, Korea Research Institute of Chemical Technology) ;
  • Lee, Chong-Ock (Pharmaceutical Screening Team, Korea Research Institute of Chemical Technology) ;
  • Lee, Kang-Ro (Natural Products Laboratory, College of Pharmacy, Sung Kyun Kwan University)
  • Published : 1999.04.01
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Abstract

A new acylcic deterpene (1) and a known acyclic diterpene 12(S)-hydroxygeranyleraniol (2) were isolated form the aerial parts of Carpesium divaricatum. The structure of 1 was determined to be (2E, 10E)-1, 12-dihydroxy-18-acetoxy-3,7,15-trimethylhexadeca-2,10,14-triene (1) on the basis of spectroscopic studies. Compounds 1 and 2 exhibited cytotoxicity against cultured human tumor cell lines, A549, SK-OV-3, SK-MEL-2, XF498, and $HCT_{15}$, with $ED_{50}$ values ranging from 4.3-10.2 ${\mu}g/ml$ and 4.1-8.3 ${\mu}g/ml$, respectively.

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