Archives of Pharmacal Research

The Pharmaceutical Society of Korea (대한약학회)
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Stereoselective Synthesis of (${\pm}$)-Epibatidine Analog(${\pm}$)-$2{\beta}$-(2-Chloro-5-pyridinyl)-8-azabicyclo[3.2.1]octane

  • Kim, Yong-Hyun (College of Pharmacy, SungKyunKwan University) ;
  • Won, Do-Youn (College of Pharmacy, SungKyunKwan University) ;
  • Oh, Chang-Young (College of Pharmacy, SungKyunKwan University) ;
  • Woo, Nam-Tae (College of Pharmacy, SungKyunKwan University) ;
  • Park, Young-Ho (Pharmaceutical & Health Science Research Institute Pacific Corporation/R & D CenterCollege of Pharmacy, Kyung Hee University) ;
  • Jeong, Jin-Hyun (College of Pharmacy, SungKyunKwan University) ;
  • Ham, Won-Hun (College of Pharmacy, SungKyunKwan University)
  • Published : 1999.06.01
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Abstract

Stereoselective synthesis of (${\pm}$)-epibatidine analog 2, which contains the 8-azabicyclo[3.2.1]octane ring system, was achieved by using palladium-catalyzed Heck-type coupling reaction from 3.

Keywords