The Determination of Enoxacin with p-Quinone Derivatives

파라퀴논 유도체와의 전하이동착물 형성을 이용한 에녹사신 정량

  • 이지연 (경성대학교 약학대학 약학과) ;
  • 김동오 (부산지방식품의약품안전청) ;
  • 남수자 (부산지방식품의약품안전청) ;
  • 정문모 (부산지방식품의약품안전청) ;
  • 허문회 (부산지방식품의약품안전청) ;
  • 안문규 (부산지방식품의약품안전청)
  • Published : 1999.08.01


Enoxacin[1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-\piperazinyl)-1,8-naphthyridine-3-carboxylic acid, ENX] is a new quinolone antibacterial agent. The method is based on the highly colored charge-transfer complex formation of this drug as a $\pi$-electron donor with 7,7,8,8-tetracyanoquinodimethane(TCNQ) or chloranil(CL) as $\pi$-acceptors. The colored products were measured spectrophotometrically at 842 nm and 552 nm for TCNQ and CL, respectively. The different experimental conditions are optimized. The linearities for TCNQ and CL were $1.6{\;}\mu\textrm{g}/mL~32{\;}\mu\textrm{g}/mL$ and $6.4{\;}\mu\textrm{g}/mL~160{\;}\mu\textrm{g}/mL$, respectively and colors were produced in non-aqueous media. This report describes a simple and ra\pid method for the analysis of enoxacin.



  1. Indian Drugs v.26 no.10 Spectrophotometric estimation of norfloxacin in its dosage forms using 3-methy-2-benzothiazo-linone hydrazone hydrochloride Rao, G. R.;Avadhanulu, A. B.;Giridhar, R.;Kokate, C. K.
  2. Indian drugs v.27 no.5 Colorimetric determination of norfloxacin in pharmaceutical formulations Rathore, Y. K. S.;Chatterjee, P. K.;Mathur, S. C.;Lal, S.;Sethi, P. D.
  3. Ind, J. Pharm. Sci. v.54 A new colorimetric method for the estimation of norfloxacin in formulations Mishra, P.;Jain, S.
  4. Anal. Lett. v.30 no.4 Spectrophotometric and spectrofluorimetric determination of pefloxacin Ahmad, A. K. S;Kawy, M. A.;Nebsen, M.
  5. Analyst v.120 Utility of certain π-acceptors for the spectrophotometric determination of norfloxacin Amin, A. S.;Sayed, G. O. E.;Issa, Y. M.
  6. Analyst v.122 Dertermination of norfloxacin in real samples by different spectrofluorimetric techniques Ruiz, T. P.;Iozano, C. M.;Tomas, V.;Carpena, J.
  7. Antimicrob. Agents Chemother. v.35 no.10 Effects of two cataions on gastrointestinal absorption of ofloxacin Cabarga, M. M.;Navapro, A. S.;Gandarillas, C.I.C.;Dominguez-gil, A.
  8. Enoxacin. Anal. Lett. v.26 no.9 polarographic behaviour and its determination in pharmaceutical forms Squella, J. A.;Lueje, A. A.;Sturm, J. C.;Vergara, L. J. N.
  9. Acta Pharm. Jugosl. v.39 Determination of norloxacin by differential pulse polarography Veber, A.;Veber, M.;Kozjek, F.;Gomissek, S.
  10. Anal. Chim. Acta v.307 Polarographic and voltammetric behaviour of ofloxacin and its analytical application Zhou, G.;Pan, J.
  11. J. Chromatogr. v.621 Simultaneous assay of fluoroquinolones and theophylline in plasma by high-performance liquid chromatography Davis, J. D.;Aarons, L.;Houston, J. B.
  12. Anal. Sci. v.7 High-perpormance liquid chromatographic determination of ofloxacin in serum Ohkubo. T.;Kudo, M.;Sugawara, K.
  13. J. Chromatogr. B. v.653 Simultaneous determination of ofloxacin, norfloxacin, norfloxacin and ciprofloxacin in human hair by high-performance liquid chromatography and fluorescence detection Mizuno, A.;Uematsu, T.;Nakashima, M.
  14. Anal. Chim. Acta v.268 A study of the prospects for a ciprofloxacin PVC coated wire ionselective electrode based on 4-quinolones Avsec, H.;Gomiscek, S.
  15. Acta Pharm. Tur. v.35 no.1 Two spectrophotometric determination methods of ciprofloxacin with brom- cresol purple and bromphenol blue Tosumoglu, S.;Savci, N.