약학회지 (YAKHAK HOEJI)

  • 제43권4호
  • /
  • Pages.437-441
  • /
  • 1999
  • /
  • 0377-9556(pISSN)
  • /
  • 2383-9457(eISSN)
대한약학회 (The Pharmaceutical Society of Korea)
권호 표지

파라퀴논 유도체와의 전하이동착물 형성을 이용한 에녹사신 정량

The Determination of Enoxacin with p-Quinone Derivatives

  • 이지연 (경성대학교 약학대학 약학과) ;
  • 김동오 (부산지방식품의약품안전청) ;
  • 남수자 (부산지방식품의약품안전청) ;
  • 정문모 (부산지방식품의약품안전청) ;
  • 허문회 (부산지방식품의약품안전청) ;
  • 안문규 (부산지방식품의약품안전청)
  • 발행 : 1999.08.01
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초록

Enoxacin[1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-\piperazinyl)-1,8-naphthyridine-3-carboxylic acid, ENX] is a new quinolone antibacterial agent. The method is based on the highly colored charge-transfer complex formation of this drug as a $\pi$-electron donor with 7,7,8,8-tetracyanoquinodimethane(TCNQ) or chloranil(CL) as $\pi$-acceptors. The colored products were measured spectrophotometrically at 842 nm and 552 nm for TCNQ and CL, respectively. The different experimental conditions are optimized. The linearities for TCNQ and CL were $1.6{\;}\mu\textrm{g}/mL~32{\;}\mu\textrm{g}/mL$ and $6.4{\;}\mu\textrm{g}/mL~160{\;}\mu\textrm{g}/mL$, respectively and colors were produced in non-aqueous media. This report describes a simple and ra\pid method for the analysis of enoxacin.

키워드

참고문헌

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