Journal of the Korean Society of Food Science and Nutrition (한국식품영양과학회지)

The Korean Society of Food Science and Nutrition (한국식품영양과학회)
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Inhibitory Effect of Coprinus comatus Ethanol Extract on the Liver damage in Benzo(a)pyrene-treated Mice

먹물버섯 에탄올추출물이 Benzo(a) pyrene 투여에 의한 마우스의 간 손상에 미치는 영향

  • 이갑랑 (영남대학교 식품영양학과) ;
  • 이병훈 (영남대학교 식품영양학과) ;
  • 김현정 (영남대학교 식품영양학과) ;
  • 장종선 (영남대학교 식품영양학과) ;
  • 배준태 (영남대학교 식품영양학과) ;
  • 박선희 (영남대학교 식품영양학과) ;
  • 이승언 (영남대학교 식품영양학과) ;
  • 김옥미 (영남대학교 식품영양학과) ;
  • 이별나 (대구공업대학 식품영양과)
  • Published : 1999.12.01
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Abstract

This study was carried out to investigate the inhibiton effects of Coprinus comatus ethanol extract of edible mushroom on liver damage in benzo(a)pyrene (B(a)P) treated mice. The activities of serum aminotransferase, cytochrome P 450 and hepatic content of lipid peroxide after B(a)P treatment were increased than those of control, but those levels were significantly decreased by the treatment of Coprinus comatus ethanol extract. Whereas, the hepatic glutathione content and glutathione S transferase activity were decreased by B(a)P treatment than those of control, but those were increased by the treatment of Coprinus comatus ethanol extract. Also the activities of superoxide dismutase, catalase and glutathione peroxidase after B(a)P treatment were markedly increased than those of control, but those levels were decreased by the treatment of Coprinus comatus ethanol extract. These results suggest that Coprinus comatus ethanol extract have a protective effect on liver damage by benzo(a)pyrene through the mechanisms of decreasing lipid peroxide and activities of free radical generating enzymes.

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