Journal of the Korean Society of Food Science and Nutrition (한국식품영양과학회지)

The Korean Society of Food Science and Nutrition (한국식품영양과학회)
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Effects of Extract of Pueraria radix on Lipid Peroxidation in Ethanol-Administered Rats

갈근추출물이 에탄올을 투여한 흰쥐의 지질과산화에 미치는 영향

  • 이정숙 (고신대학교 식품영양학과) ;
  • 김은실 (동아대학교 식품영양학과) ;
  • 김석환 (동아대학교 식품영양학과)
  • Published : 1999.08.01
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Abstract

This study was designed to investigate the effect of Pueraria radix extract on lipid peroxidation in ethanol administered rats. Male sprague dawley rats were given 25% ethanol(2.5g per Kg body weight; E), 10% pueraria radix extract(CP), 25% ethanol and 10% pueraria radix extract(EP). The activity of hepatic superoxide dismutase was increased by ethanol and was lower in the EP group than in the E group. Hepatic catalase activity was increased by ethanol, but decreased by Pueraria radix extract. E group rats had significantly higher liver glutathione peroxidase activity. Activity of hepatic glutathione S transferase was higher in the CP group than in the other groups. No significant dif ferences was found in liver glutathione and lipid peroxide contents between control and EP group. These data indicate that the peroxidative damage associated with chronic ethanol consumption might be decreased by Pueraria radix extract.

체중증가량은 에탄올-갈근급여군에서 가장 낮게 나타났으며, 식이섭취량은 갈근급여군들이 대조군보다 감소하였다. 식이효율은 갈근단독급여군이 가장 높았고, 에탄올-갈근급여 군은 대조군과 차이를 보이지 않았다. Superoxide dismutase의 활성은 에탄올단독급여군이 가장 높았고, 에탄올-갈근급여군은 에탄올단독급여군보다 감소를 보였다. Catalase의 활성은 에탄올단독급여군에서 대조군보다 증가를 나타냈으며, 에탄올단근급여군에서는 에탄올 단독급여군보다 감소 경향을 보였다. 간조직의 glutathione peroxidase 활성은 에탄올단독급여군이 가장 높게 나타났으며, glutathione S-transferase의 활성은 갈근단독급여군이 가장 높았다. 간조직 중의 glutathion 함량은 에탄올 단독급여군이 가장 낮았고, 에탄올-갈근급여군은 에탄올단독급여군에 비해 높은 경향을 보였다. 간의 과산화지질 함량은 에탄올단독급여군이 가장 높았고, 에탄올 갈근급여군은 에탄올단독급여군에 비해 감소하는 경향을 보였다. 혈청 중의 ALT, AST의 활성은 에탄 옹단독급여군에서 가장 높게 나타났고, 에탄올 갈근급여군은 대조군과 비슷하였다. 이상의 결과를 종합해 볼 때, 에탄올 급여로 인해 생성된 free radical에 의해 야기되는 체내 과산화적 손상은 갈근추출물을 급여시킴으로써 경감시킬 수 있을 것으로 사료된다.

Keywords

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