Effect of Portulaca oleracea Extract in Removing Nicotine Component of Tobacco

쇠비름 추출물이 담배의 Nicotine 성분 제거에 미치는 영향

  • 배지현 (계명대학교 식품영양학과)
  • Published : 1999.06.01

Abstract

Cigarette smoking is the potential risk factor for lung cancer and chronic pulmonary disease, as well as inflammatory bowel disease and reproductive malfunction. Nicotine and tar have been im plicated as a major factor in the pathogenesis of the diseases. Nicotine increases heart rate and blood pressure due to stimulation sympathetic neurotransmission and tar also accounts for the severe damage of peridontal diseases and osteoporosis in postmenopausal women. Portulaca oleracea, which contains significant amount of K+, noradrenaline and dopamine as well as various nutrients, has been used for many medicinal purposes and one of which is the detoxification of insect or snake toxins. The purpose of this study was to investigate the action of Portulaca oleracea extracts on the reduction of harmful materials of tabacco. The reduction percentages were measured in the presence and absence of each solvent extract of Portulaca oleracea using reversed C18 column of HPLC. Nicotine reduction effects were obtained from aqueous, methanol and chloroform extracts of Portulaca oleracea as 89%, 55% and 51%, respectively. The results suggest that the polar extracts of Portulaca oleracea affects the reduction of nicotine which is responsible for many diseases.

Keywords

References

  1. Cardiovasc Drugs Ther. v.12 Cardiovascular safety of transdermal nicotine patches in patients with coronary artery disease who try to quit smoking Tzivoni, D.;Keren, A.;Meyler, S.;Khoury, Z.;Lerer, T.;Brunel, P.
  2. Cardiovasc Drugs Ther. v.10 Nicotine and sympathetic neurotransmission Haass, M.;Kepler, W.
  3. J. Health Care Poor Underserved v.8 Cadiovascular implications of smoking: the surgeon general's point of view Manley, A. F.
  4. Ann. NY Acad. Sci. v.833 Tobacco and cancer: approaches using carcinogen biomarkers an chemoprevention Hecht, S. S.
  5. Stat. Methods Med. Res. v.7 Lung cancer and passive smoking Hackshaw, A. K.
  6. Carcinogenesis v.19 Signalling pathways involved in nicotine regulation of apoptosis of lung cancer cells Heusch, W. L.;Maneckjee, R.
  7. Proc. Natl. Acad. Sci. USA v.95 Nerve growth factor abrogates the tumorigenicity of human small cancer cell lines Missale, C.;Codignola, A.;sigala, S.;Finardi, A.;Paez, P. M.
  8. Eur. Respir. J. v.12 Cigarette smoke inhalation and lugn damage in smoking volunteers Clark, K. D.;Wardrobe, W. N.;Elliott, J. J.;Gill, P. Y.;Tait, N. P.;Snashall, P. D.
  9. J. Clin Gastroenterol. v.25 Is smoking still important in the pathogenesis of peptic ulcer disease? Eastwood, G. L.
  10. Early Pregnancy v.3 Influence of micotine on progesterone and estradiol production of cultured human granulosa cells Tinneberg, H. R.;Borsay, P.
  11. J. La State Med. Soc. v.150 Exercise is medicine : health benefits of regular physical activity Burnham, J. M.
  12. Psychoneuroendocrinology v.23 Endocrine effects of micotine administranion, tobacco and other drug withdrawal in humans Pickworth, W. B.;Fant, R. V.
  13. Brain Res. Mol. Brain Res. v.49 Neuronal micotinec acetylcholine receptor in the hypothalamus: morphological diversity and neuroendocrine regulations Shioda, S.;Nakajo, S.;Hirabayashi, T.;Nakayama, H.;Nakaya, K.;Matsuda, K.;Nakai, Y.
  14. Neurosci Res. v.29 Nicotine increases cytosolic Ca2+ in vasopressin neurons Shioda, S.;Yada, T.;Muroya, S.;Takigawa, M.;Makai, Y.
  15. Coloured medicinal plants of Korea Youk, C. S.
  16. Natrue v.191 High concentration of (-)-Noradrenaline in Portulaca oleracer L. Peng, P. C.;Haynes, L. J.;Magnus, K. E.
  17. Plant Foods for Human Nutr. v.45 Chemical momposition of purslane(Protulaca olercea) Mohamed, A. I.;Hussein, A. S.
  18. Standard Method No. 10 CORESTA
  19. J. Chromatogr. v.708 Rapid and sensitive high-performance liquid chromatographic determination of micotine and cotinine in nonsmoker human and rat urines Oddoze, C.;Pauli, A. M.;Pastor, J.
  20. Cancer Res. v.59 Quantitation of urinary metabolites of a tobacco-specific lung cancer after smoking cessation Hecht, S. S.;Carmella, S. G.;Chen, M.;Miller, A. T.;Murphy, S. J.;Zimmerman, C. L.;Hatsukami, D.K.
  21. J. Toxicol. Environ. Health v.50 the changing cigarette, 1950-1995 Hoffmenn, D.;Hoffmann, I.
  22. J. Can. Dent. Assoc. v.63 Tobacco smoking and periodontal diseases Qandil, R.;Sandhu, H. S.;Matthews, D. C.
  23. HPLC columns: Technology and Practice Neue, U. D.
  24. J. Am. Coll. Nutr. v.11 Common purslane: a source of omega-3 fatty acids and antiosidants Simopoulos, A. P.;Norman, H. A.;Gillaspy, J. E.;Duke, J. A.
  25. J. Ethnopharmacol. v.22 Effect of an aqueous extract of Portulaca oleracea leaves on smooth muscle and rat blood pressure Parry, O.;Okwuasaba, F.;Ejike, C.
  26. J. Ethnopharmacol. v.40 the muscle relaxant properties of Portulaca oleracea are associated with high concentratios of potassium ions Habtemariam, S.;Harvey, A. L.;Waterman, P. G.
  27. J. Ethnopharmacol. v.40 The skeletal muscle relaxant action of portulaca oleracea: role of potassium ions Parry, O.;Marks, J. A.;Okwuasaba, F. K.
  28. J. Ethnopharmacol. v.19 Skeletal muscle relaxant action of an aqueous extract of Portulaca oleracea in thr rat Parry, O.;Marks, J. A.;Okwuasaba, F. K.;Ejike, C.