Journal of the Korean Society of Food Science and Nutrition (한국식품영양과학회지)

The Korean Society of Food Science and Nutrition (한국식품영양과학회)
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Bone Growth and Calcium Metabolism in Mouse Affected by Dietary Calcium and Calcium-regulating Hormone Administration

생쥐의 골격성장과 Ca대사에 미치는 식이 Ca과 칼슘조절 호르몬의 영향

  • 정차권 (한림대학교 식품영양학과) ;
  • 한은경 (한림대학교 식품영양학과) ;
  • 남상명 (한림대학교 식품영양학과) ;
  • 문유선 (의과대학 가정의학과) ;
  • 최수용 (한국원자력병원 임상의학실) ;
  • 하경선 (한림대학교 식품영양학과)
  • Published : 1999.06.01
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Abstract

This study has dealt the effect of Ca regulating hormones and dietary Ca levels on Ca metabolism. Animals(BALB/c mice) were divided into three dietary groups(high and medium Ca and Ca free) and hormones including parathyroid hormone(PTH), calcitonin(CT), cholecalciferol(Vit D) were i.p. injected. After feeding experimental diets for five weeks, mice were anaethetized and sacrificed by heart puncture. We found that femur growth of mouse was slightly increased by high dietary Ca without showing statistical significance comparing to low dietary Ca group. The combination of PTH and CT showed the same effect when dietary Ca was high. At the same time, total mineral retention in bone was most affected by dietary Ca. In general, high Ca diet elevated Ca level in the serum. When dietary Ca was low, PTH stimulated Ca release from the bone into the serum, which was shown to be inhibited by CT treatment. Comparing to the control, PTH, Vit D and CT together tended to inhibit serum Ca level at high and medium dietary Ca. PTH and Vit D inhibited Ca reserve in the liver at all dietary levels of Ca. Both PTH and Vit D stimulated bone Ca retention when dietary Ca was low, but this effect was reversed when dietary Ca was high. When PTH, Vit D and CT were administered together, bone Ca level was greatly enhanced at low dietary Ca than at high dietary Ca, which suggests that these hormonal cooperation is needed for proper bone density maintenance especially when dietary minerals are not sufficient.

Keywords

References

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