Journal of the Korean Society of Food Science and Nutrition (한국식품영양과학회지)

The Korean Society of Food Science and Nutrition (한국식품영양과학회)
권호 표지

Effects of Nuruk or Wheat Bran Supplemented Diet on the Serum Levels of Cholesterol and Activities of Hepatic Oxygen Free Radical Metabolizing Enzymes in Rats

누룩 또는 밀기울 첨가식이로 성장시킨 흰쥐의 혈중 Cholesterol 및 간조직 유해산소 대사효소 활성 변동

  • Published : 1999.02.01
Download PDF
⟨ Previous Next ⟩

Abstract

The effects of nuruk and wheat bran on cholesterol level in serum and activities of free radical metabolizing enzymes were investigated in rats. The rats were fed a diet containing nuruk or wheat bran for one month. Body weight and food intake were measured. Animals were sacrificed after one month. The increased food efficiency ratio throughout whole growth period was observed in the rats fed with either nuruk containing Aspergillus terreus or wheat bran compared with control group on normal diet. In the rats fed with nuruk, hepatic GSH content, glutathione S transferase activity, hepatic cytochrome P 450 content, and aniline hydroxylase activities were generally increased. In the rats fed with nuruk containing other fungi except Aspergillus terreus, xanthine oxidase activity was decreased. The decreased cholesterol level in serum was observed in rats fed with nuruk prepared from Aspergillus terreus and wheat bran. LDL cholesterol level was decreased in rats fed with nuruk prepared with other fungi such as Penicillium sp. and Rhizopus sp. But HDL cholesterol level was increased in all groups fed with nuruk from any fungi and wheat bran. These results suggested that nuruk or wheat bran supplemented diet might exert their effect by decreasing cholesterol level in serum and amount of oxygen free radical level.

Keywords

References

  1. Korean J. Dietary Culture v.4 History of Korean spirits Chang, S. H.
  2. J. Korean Soc. Food. Sci. Nutr. v.26 Characteristics of useful fungi isolated from traditional Korean nuruk Kim, H. S.;Hyun, J. S.;Kim, J.;Ha, H. P.;Yu, T. S.
  3. J. Ind. Microbiol. v.8 Mustant of a lovastarin-hyperproducing Aspergillys terreus deficient in the production of sulochrin Vinci, V. A.;Hoermer, T. D.;Coffman, A. D.;Schimmel, T. G.;Dabora, R. L.;Kirpekar, A. C.;Ruby, C. L.;Stieber, R. W.
  4. J. Biol. Chem. v.249 Glutathinoe S-transferase: The first enzymatic step in mercaptric acid formation Habig, W. H.;Pabist, M. J.;Jakoby, W. B.
  5. Federal Process v.20 Circadian susceptibilty rhythm of mice to librium Marte, E.;Halberg, F.
  6. J. Biol. Chem. v.244 The regulation of rat liver xanthine oxidase Stripe, F.;Della Corte, E.
  7. Am. J. Clin. Pathol. v.28 A colorimetric method for the determination of serum glutamic oxaloacetic acid and glutamic pyruvic transaminase Reitman, S.;Frankel, S.
  8. J. Biol. Chem. v.193 Protein measurement with folin phenol reagent Lowry, O. H.;Rosebrough, N. J.;Farr, A. L.; Randall, R. L.
  9. Arch. Biochem. Biophys. v.82 Tissue sulfhydryl group Ellman, G. L.
  10. Anal. Biochem. v.95 Assay for lipid peroxide in animal tissues by thiobarbituric acid reaction Ohkawa, H.;Ohish, N.;Yaki, K.
  11. Clin. Chem. v.20 Enzymatic determination of total serum cholesterol Allain, C. C.;Poon, L. S.;Chan, C. S. G.;Richmond, W.;Fu, P. C.
  12. Clin. Chem. v.24 Enzymatic determination of cholesterol in serum lipoproteins separated by electrphoresis Cobb, S. a.;Sanders, J. L.
  13. Br. J. Nutr. v.55 Absence of effects of dietary wheat barn on the activities of some key enzymes of carbohydrate and lipid metabolism in mouse liver and adipose tissue Stanley, J. C.;Lambadarios, J. A.;Newsholme, E. A.
  14. J. Inst. Sci.(Keimyung University) v.10 An effect of carbon tetracholride treatment on the activity of small intestinal hepatic alanine aminotransferase in rats Yoon, C. G.;Shin, J. K.;Chung, K. S.
  15. Adv. Enzymol. v.32 The role of glutathione and glutathinoe S-transferase in mercapturic acid biosynthesis Boyland, E.;Chasseud, L. F.
  16. J. Biol. Chem. v.251 Properties of electrophoretically homogenous phemobarbital-inducible and A-naphthoflavone-inducible forms of liver nicroxomal cytochrome P-450 Haugen, D. A.;Coon, M. J.
  17. Cell. Biol. Int. Rep. v.2 Biochemical mechanism accounting for the toxic action of oxygen on living organisms: The key role of superoxide dismutase Halliwell, b.
  18. J. Inst. Life Sci.(Keimyung University) v.6 Changes in liver and serum xanthine oxidase activity following administration of carbon tetrachloride in rats Yoon, J. G.