Effect of Calcium Supplementation on Blood Pressure Response to Dietary Soldium Level in Normotensive Young Korean Women with Family History of Hypertension

칼슘의 보충섭취가 식이 나트륨 섭취수준에 따른 혈압 변동에 미치는 영향

  • Published : 1999.09.01

Abstract

Effects of Ca supplementation on blood pressure(BP) response to dietary Na level were studied in 15 normotensive healthy college women with family history of hypertension. All subjects, randomly divided into 3 groups, ate low Na diet(1816mg/day) prepared in the laboratory during the first 2 weeks and normal Na diet(4064mg/day) of their own home for the next 8 weeks. The one group received daily 1g Ca supplement at both low and normal Na diet periods, the second group took daily 1g Ca supplement only at normal a diet period, and the last group took placebo during both periods. Average Ca and energy intakes at the basal of and during the trial ranged 450-600mg and 1735-1878kcal, respectively. Systolic/diastolic BP was decreased by 9.2-9.8/4.4-4.5 mmHg during low Na diet period and was increased again during next normal Na diet period. However simultaneous Ca supplementation during both low and normal Na diet period suppressed the elevation of systolic/diastolic BP occurred at normal Na diet period. Ca supplementation only at normal Na diet peroid did not affect the BP elevation. The increase of serum Ca and Ca/Mg ratio and the decrease of serum Na and Na/K ratio might be related to the BP lowering effects of Ca supplementation. In conclusion, Ca supplement could attenuate BP elevation induced by increasing Na intake. The BP lowering effect of Ca supplementation was not appeared at low Na intake. Further studies were needed to make it certain. Low Na intake was also confirmed as an effective diet control for lowering blood pressure.

Keywords

References

  1. Annual report on the cause of death statistics National Statistical Office
  2. N Engl J Med v.317 Salt sensitive essential hypertention in men. Is the sodium ion alone important? Kurtz TW;Al-Bander HA;Morris RC
  3. Nutrition in Health and Disease(8th ed) Nutrition, diet, and hypertention Kotchen TA;Kotchen JM;Shils ME(ed);Olson JA(ed);Shike M(ed)
  4. J Hypertention v.8 Non-pharmacological treatment of hypertention Silverberg DS
  5. Science v.217 Dietary calcium in human hypertention McCarron DA;Morris CD;Cole C
  6. Am J Hypertens v.5 Epidemiological evidence of an interaction between calcium and sodium intake impacting on blood pressure: A Montreal study Hamet P;Daignault-Gelinas M;Lambert J;Ledoux M;Whissell-Camiotti L;Bellavance F;Mongeau E
  7. Korean J Community Nutrition v.1 no.1 Dietary factors and serum and urinary electrolytes affecting blood pressure in adolescents Lee JW;La HS;Kwak CS
  8. Korean J Community Nutrition v.1 no.2 Blood pressure distribution of adolescents in Taejon city and its relationship with obese index and several environmental factors Lee JW;La HS
  9. Hypertention v.21 Alterations in calcium metabolism in young people at risk for primary hypertention: the Dutch hypertention and offspring study Van Hooft IMS;Grobbee DE;Frolich M;Pols HAP;Hofman A
  10. Hypertention v.23 Dietary calcium and blood pressure in experimental models of hypertention: a review Hatton DC;McCarron DA
  11. Am J Hypertens v.3 Calcium and blood pressure: an epidemiologic perspective Cutler JA;Brittain E
  12. Am J Clin Nutr v.55 Calcium supplementation on normotensive and hypertensive pregnant women Knight KB;Keith RE
  13. Am J Hypertens v.6 The blood pressure effects of calcium supplementation in humans of known sodium responsiveness Weinberger MH;Wagner UI;Fineberg NS
  14. Korean J Nutrition v.21 no.4 The effect of calcium supplementation on blood pressure in normotensive young Korean adults Lee JW;Kim HY
  15. Korean J Nutrition v.26 no.6 Effects of dieatary calcium levels on blood pressure and calcium metabolism in normotensive female young adults with the hypertention family history Lee JW;Hwang YS;Hong SN;Im HS
  16. '95 National Nutrition Survey Report '95 National Nutrition Survey Report Ministry of Health and Welfare
  17. Food Composition Table(4th revision) National Rural Living Science Institute
  18. A study on the survey methods of food consumption Food Research Center, Korean Society of Food Industry
  19. Korean foods-history and cookery Yoon SS
  20. A study on Na and K contents of Korean processed foods J the Graduate School of Education Park JA
  21. Am J Clin Nutr v.23 Usefullness of overnight urines in population groups Watson RL;Langford HG
  22. Korean J Nutrition v.18 no.3 A study on the sodium and potassium intake on their metabolism of university student in Korea Park TS;Lee KY
  23. Korean J Nutriton v.30 no.1 The effects of calcium supplementation on the metabolism of sodium and potassium and blood pressure in college women Kim HS;Yu CH
  24. Korean J Nutrition v.20 no.5 Measurement of Na intake in Korean adults females Kim YS;Paik HY
  25. Hypertention v.32 no.5 Importance of the renin system in determining blood pressure fall with salt restriction in black and white hypertensives He FJ;Markandu ND;Sagnella GA;MacGregor GA
  26. Salt sensitivity in normotensives with and salt resistance in normotensives without heredity of hypertention Skabal F;Hamberger H;Genry E
  27. JAMA v.267 no.9 The effect of nonpharmacologic interventions on blood pressure of persons with high normal levels Hypertention Prevention Collaborative Research Group
  28. J Am Diet Assoc v.95 Blood pressure responses of white men with hypertention to two low-sodium metabolic diets with different levels of dietary calcium Wendy AL;Melinda MM;Linda AV;Steven SC;Laurel VH;James F
  29. Am J Hypertention v.1 Erythrocyte cation metabolism in salt-sensitive hypertensive blacks as affected by dietary sodium and calcium Zemel MB;Kraniak J;Standly PR;Sowers JR
  30. Am J Hypertention v.4 no.6 Sodium excretion and plasma renin activity in normotensive and hypertensive black adults as affected by dietary calcium and sodium Zemel MB;Gauloni SM;Sowers JR
  31. J Lab Clin Med v.114 Calcium and hypertention Sowers JR;Zemel MB;Standly PR;Zemel PC
  32. Am J Clin Nutr v.54 Dietary Ca²+ prervents NaCl-sensitive hypertention in spontaneously hypertensive rats via sympatholic and renal effects Suzanne O;Chen YF;Jin HK;Yang RH; J Michael W
  33. Chungnam J Life Science Research v.11 no.1 Effects of dietary calcium levels on serum lipids in normotensive female young adults with hypertention family history Hong SN;Lee JW
  34. Korean J Nutrition v.22 no.6 Serum total calcium, ionized calcium ion and lipid compositions in hypertensive Koreans Park KH;Park HS
  35. Ann Intern Med v.103 Blood pressure response to oral calcium in persons with mild to moderate hypertention McCarron DA;Morris CD
  36. Am J Clin Nutr v.42 Effects on blood pressure of calcium supplementation of women Johnson NE;Smith EL;Freudenheim JL
  37. Am J Med v.64 The effects of high-sodium and low-sodium intakes on blood pressure and other related variables in human subjects with idiopathic hypertention Kawasaki T;Delea CS;Baruer FC;Smith H
  38. Korean J Nutrition v.20 no.4 Effects of sodium intake levels on calcium metabolism in Korean female adults Kim YA;Sung JJ
  39. Am J Med v.72 Sodium sensitivity and resistance in normotensive humans Lufs F;Weinberger M;Grim C
  40. Ann Rev Nutr v.1 Sodium and Potassium Fregly MJ
  41. J Am Diet Assoc v.92 Effects of dietary calcium from dairy products on ambulatory blood pressure in hypertensive men Kynast-Gales S;Massey L
  42. A study on sodium and potassium intakes and their metabolism of preschool children in Seoul area v.20 no.1 Lee KY;Kim EY
  43. Korean J Nutrition v.16 no.3 Urinary sodium and blood pressure in Korea child Lim HS;Lee YS
  44. Circulation v.70 no.1 The effects of familial relationships, age, body weight and diet on blood pressure and 24-hour urinary excretion of sodium, potassium and creatinine in man, woman and children of randomly selected families Connor S;William E;Connor E;Henry H;Sexton G;Keenan E
  45. J Institute of Korean Food Culture v.5 Effects of diets adequate or deficient in calcium on sodium metabolism and blood pressure in female young adults Lee JW
  46. Korean J Nutrition v.25 no.2 A Comparative study on urinary Ca excretion in young and middle-aged Korean women Cho JH;Paik HY
  47. Am J Hypertens v.11 no.10 Effects of potassium supplementation on office, home, and 24-h blood pressure in patients with essential hypertention Kawano Y;Mimami J;Takishita S;Omae T
  48. JAMA v.267 Inverse association of dietary calcium with systolic blood pressure in young children Gillman MW;Oliveria SA;Moore LL;Ellison C